Evidence map›Paper›PMID 41646403›Full record

ArticleResearch square2026

NR4A1 limits CD8

Samreen Fatima, Yao Chen, Lorissa Smulan, Basanthi Satish, Mike Jameson, Sheetal Saini, Calvin Johnson, Alicia Tay, Shihui Foo, Hedayathulla Rahmathulla and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Samreen FatimaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Yao ChenA*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.
Lorissa SmulanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Basanthi SatishDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mike JamesonDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sheetal SainiA*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.
Calvin JohnsonDivision of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alicia TaySingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.
Shihui FooSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.
Hedayathulla RahmathullaSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.
Akhila BalachanderSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.
Shanshan W HowlandSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.ORCID 0000-0003-4794-1564
Hardy KornfeldDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8970-7306
Amit SinghalDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID https://orcid.org/0000-0003-3913-8798

Funding

Lung-Protective Mechanisms of Metformin in TBR01HL152078 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY, SINGHAL, AMIT · 2021 to 2024
$2.5M
Sirtuins and Host Metabolism in TB Pathogenesis and TreatmentR01HL153162 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY, SINGHAL, AMIT · 2021 to 2024
$2.5M
Unleashing CD8+ T Cells for TB DefenseR21AI185410 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORNFELD, HARDY · 2024 to 2025
$447k
NHLBI NIH HHS R01 HL152078NHLBI NIH HHS R01 HL153162NIAID NIH HHS R21 AI185410
6 · The paper itself

Abstract

During

Indexed as

CD8+ T cellsgranulomahost-directed therapyNR4A1T cell infiltrationTuberculosis

Identifiers

PMID41646403
PMCPMC12869613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.