ArticleResearch square2026
Ascending and descending motor pathways converge in the centrolateral nucleus of the thalamus.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Corollary discharge (CD) signals are copies of motor commands that inform the brain of impending movements. Dysfunction in CD has been implicated in a variety of disorders, from schizophrenia to Parkinson's disease. In the current study, we used intersectional viral tracing techniques, electron microscopy, and dual opsin optogenetics to investigate potential CD circuits in mice. We focused on the centrolateral (CL) nucleus of the thalamus to relate our findings to previous studies of CD carried out in primates. We found that single neurons in the CL integrate ascending inputs from premotor neurons in the superior colliculus with descending inputs from neurons in layer 5 of the motor cortex; these integrated signals are subsequently sent to the striatum and motor cortex. These results suggest that CL circuits may detect the relative timing of cortical and subcortical movement commands, providing an important feedback loop for ongoing adjustments of movement planning and initiation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.