Evidence map›Paper›PMID 41646391›Full record

ArticleResearch square2026

Sex specific effects of adoptive Tregs transfer on the brain and periphery in maternal immune activation offspring rescuing immune dysregulation.

Destanie Rose, Rachel Moreno, Hadley Osman, Megan Rowland, Jill Silverman, Annie Ciernia, Paul Ashwood

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Destanie RoseUniversity of California, Davis.
Rachel MorenoUniversity of California, Davis.
Hadley OsmanUniversity of California, Davis.
Megan RowlandUniversity of British Columbia.
Jill SilvermanUniversity of California, Davis.
Annie CierniaUniversity of British Columbia.
Paul AshwoodUniversity of California, Davis.

Funding

Immune regulation and gastrointestinal co-morbidity in autism spectrum disordersR01HD090214 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2018 to 2022
$1.9M
Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311k
NICHD NIH HHS R01 HD090214NIH HHS S10 OD010786
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is characterized by atypical communication, social interactions, and restricted interests. In ASD, there are dysfunctional immune regulatory control mechanisms that can lead to immune activation. Notably lower frequencies of regulatory T cells (Tregs) and reduced immunosuppressive cytokines are reported and associated with more impaired behaviors impacting both individuals with autism and their families. Therefore, therapeutic approaches that enhance immune regulation may offer substantial benefits. Using the maternal immune activation (MIA) model, we investigated whether adoptive transfer of wildtype Tregs into MIA offspring recipients could rescue immune activation, brain transcriptome changes and behaviors exhibited in adult MIA offspring. We also aimed to explore potential sex-differences in responses. In male but not female MIA offspring, Tregs transfer reduced the frequency of T helper (T

Indexed as

autismbehaviorgene expressionimmune regulationinflammationmaternal immune activation (MIA)regulatory T cells (Tregs)schizophreniasexTH17 cells

Identifiers

PMID41646391
PMCPMC12869585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.