ArticleResearch square2026
Fentanyl decreases blood oxygen more than furanylfentanyl despite similar effects on breathing.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rationale: Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence, the Objectives: To characterize furanylfentanyl relative to fentanyl Methods: The affinity and potency of fentanyl and furanylfentanyl were determined in CHO cells overexpressing MOR. Male and female mice were administered ( Results: Furanylfentanyl behaves as a partial agonist Conclusions: These results highlight the complexity of fentanyl-induced respiratory depression and indicate that recreational use of 2-furanylfentanyl in humans may pose a greater risk of overdose than morphine but lesser than fentanyl.
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