ArticleResearch square2026
Contextual variability in under-diagnosed cardiometabolic disease and cognitive vulnerability among populations at high risk for Alzheimer's disease and related dementias.
Nwanyieze Jiakponnah, Joseph Curran, Tamlyn Watermeyer, Jasmit Shah, Litha Musili, Stanley Onyango, Benard Aliwa, Andy Mackelfresh, Omonigho Michael Bubu, Chiadi Onyike and 10 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors.
Nwanyieze JiakponnahWake Forest University.
Joseph CurranWake Forest University.
Tamlyn WatermeyerNorthumbria University.
Jasmit ShahAga Khan University Nairobi.
Litha MusiliAga Khan University Nairobi.
Stanley OnyangoAga Khan University Nairobi.
Benard AliwaAga Khan University Nairobi.
Andy MackelfreshUniversity of North Carolina at Charlotte.
Omonigho Michael BubuNew York University.
Chiadi OnyikeJohns Hopkins University.
Ozioma OkonkwoUniversity of Wisconsin-Madison.
Zul MeraliAga Khan University Nairobi.
Rufus AkinyemiUniversity of Ibadan.
Timothy HughesWake Forest University.
Mansoor SalehAga Khan University Hospital Nairobi.
Melissa PetersenUniversity of North Texas Health Science Center.
Karen BlackmonDartmouth-Hitchcock Medical Center.
Adesola OgunniyiUniversity College Hospital, Ibadan.
Hugh HendrieIndiana University.
Chinedu Udeh-MomohWake Forest University.
Funding
The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Sid E O'Bryant · 2022 to 2026
$181.1MHealth and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MINDIANAPOLIS/IBADAN DEMENTIA PROJECTR01AG009956 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI HALL, KATHLEEN S · 1991 to 2010
$14.0MHealth Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6MLook AHEAD Sleep: Sleep-disordered breathing, circadian rest/activity rhythms, and the risk of Alzheimer's disease and related dementias in Look AHEADR01AG074562 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Adam Peter Spira, Chinedu Theresa Udeh-Momoh · 2021 to 2026
$8.8MEvaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer DetectionR01CA241758 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALLAF, MOHAMAD, HU, JIM · 2020 to 2024
$3.1MScalable Technologies for the Assessment and Rescue of Brain Health: Brain-STARTU01AG097744 · NIA · AGA KHAN UNIVERSITY (KENYA) · PI Karen Blackmon, Zul Merali · 2025 to 2026
$887kNCI NIH HHS R01 CA241758NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG009956NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS R01 AG074562NIA NIH HHS U01 AG097744NIA NIH HHS U19 AG078109Wellcome Trust
6 · The paper itselfAbstract
Underdiagnosis of cardiometabolic risk factors (CMRFs) may represent an unrecognised biological pathway contributing to dementia risk; yet remains poorly characterised in African and African diaspora populations. We quantified the prevalence and determinants of underdiagnosed hypertension and abnormal glycaemia across four cohorts comprising up to 7,000 adults aged ≥ 40 years from Nigeria, Kenya, and The United States: Indianapolis, and North Texas. Underdiagnosis was defined as absence of self-reported diagnosis despite elevated systolic blood pressure (≥ 130 mmHg) or fasting blood glucose (≥ 100 mg/dL). Cohort-stratified analyses examined demographic, socioeconomic, cognitive, Alzheimer's genetic, and blood-based biomarker correlates. Underdiagnosis was pervasive in African cohorts. Elevated fasting glucose was associated with cognitive impairment in Kenya and North Texas, while severe hypertension and diabetes were linked to Alzheimer's disease-related biomarkers [pTau217/181, NFL and Aβ42/40] in North Texas (
Identifiers
PMID41646354
PMCPMC12869697
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390