ArticleResearch square2026
Chemotherapy-induced neuropathy (CIN) persists chronically for most individuals with breast cancer who develop the condition: A survey study.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
Purpose: A majority of individuals treated with taxane agents for breast cancer (BC) develop chemotherapy-induced neuropathy (CIN) yet questions remain regarding long-term prognosis of this neurologic complication. We sought to characterize CIN chronicity in terms of persistence rate, predictors, and neuromotor dysfunction. Methods: We surveyed individuals with BC who developed CIN during taxane exposure at least 3 months prior. We calculated the proportion of survey respondents with/without chronic CIN symptoms and performed a sensitivity analysis, computing the largest and smallest possible rate of CIN chronicity given the number of non-respondents. Additionally, we analyzed predictors of chronicity (e.g., age, hgA1c level) and characterized the proportion of individuals with chronic sensory symptoms who also demonstrated neuromotor dysfunction. Results: We surveyed two hundred and fifty-eight individuals (99.2% female). Mean(SD) age = 60.5(11.1); time since last taxane exposure = 3.25(2.38) years; and A1C = 5.64(0.607). Persistent CIN sensory symptoms were reported by 84.9% [95% CI 79.5%, 90.3%]. Accounting for both the non-response sensitivity analysis and statistical uncertainty, we calculate bounds for the CIN persistence rate to be no lower than 50.5% and no higher than 93.6%. Variables predictive of CIN chronicity included high A1C (p = 0.037). Variables not predictive included total chemotherapy dose (p = 0.8); race (white vs non-white, p = 0.4); age (p = 0.09); time since last taxane exposure < 6 years (p = 0.051). Among those with chronic CIN, 85% demonstrated quantifiable neuromotor dysfunction. Conclusion: CIN symptoms persist chronically for most individuals (~ 85%) with breast cancer who develop the condition during taxane treatment. Novel interventions are needed to alleviate sensory symptoms and associated neuromotor dysfunction.
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