ArticleResearch square2026
Genetic Insights into the Rheological Phenotype of Candida albicans Biofilms.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
Abstract
The opportunistic fungal pathogen Candida albicans forms biofilms with viscoelastic properties and rheological response to flow that can significantly impact its biology and life cycle. The rheological phenotypes of fungal biofilms, however, have been neither quantified extensively nor genetically dissected. We have developed methods to quantify the rheology of fungal biofilms, and, here, we analyzed a panel of C. albicans deletion mutants impaired in cell wall structure or extracellular matrix (ECM) production for rheological phenotypes. Increased elastic moduli, indicative of higher viscoelasticity, were evident in strains singly deleted for ALG11, KRE5, and PMR1, with complementation strains showing wild-type phenotypes. The deletion mutants exhibited a smooth biofilm morphology on agar, with reduced hyphae, decreased ECM, and decreased fluconazole resistance. Transcriptional profiling of these strains identified altered expression of genes affecting cell membrane/cell wall biology, translation, protein catabolism, lipid metabolism, and filamentous development. Collectively, the data present C. albicans biofilm rheology as a distinct phenotype affected by ECM production and cell morphology, while identifying genes for the further investigation of fungal biofilm viscoelasticity.
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Registered trials
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