Evidence map›Paper›PMID 41646325›Full record

ArticleResearch square2026

IFN-γ protects the human blood-brain barrier from Toxoplasma gondii-mediated dysfunction via CCL2 suppression.

Mia C Somenzi, Kameron T Bell, Abigail M Bitters, Collin S Stratton, Samantha R Springston, Kamryn E Zadeii, Rylee J Anderson, Daisy Woellner-Santos, Scott G Canfield, Américo H López-Yglesias

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mia C SomenziIndiana University School of Medicine.
Kameron T BellIndiana University School of Medicine.
Abigail M BittersIndiana University School of Medicine.
Collin S StrattonIndiana University School of Medicine.
Samantha R SpringstonIndiana University School of Medicine.
Kamryn E ZadeiiIndiana University School of Medicine.
Rylee J AndersonIndiana University School of Medicine.
Daisy Woellner-SantosIndiana University School of Medicine.
Scott G CanfieldIndiana University School of Medicine.
Américo H López-YglesiasIndiana University School of Medicine.

Funding

Microphysiological systems to Advance Precision medicine for Alzheimer's Disease and Related Dementias (MAP-AD)U54AG090792 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Timothy I Richardson · 2025 to 2026
$9.9M
T-bet-regulated myeloid innate defense against Toxoplasma gondiiR01AI168056 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI AMERICO HARRY LOPEZ-YGLESIAS · 2023 to 2026
$1.3M
NIAID NIH HHS R01 AI168056NIA NIH HHS U54 AG090792
6 · The paper itself

Abstract

The obligate intracellular parasite

Identifiers

PMID41646325
PMCPMC12869668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.