Evidence map›Paper›PMID 41646298›Full record

ArticleResearch square2026

Ameloblastin Amphipathic Helix Motif mediates Ameloblast Polarization and Prismatic Enamel Formation via a RhoA Signaling Pathway.

Gayathri Visakan, Rucha Arun Bapat, Jing Cai, Ethan Trevor Suwandi, Derk Joester, Natalie C Kegulian, Edwin Sarkisians, Marziyeh Aghazadeh, Simon Webster, Janet Moradian-Oldak

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Gayathri VisakanCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Rucha Arun BapatCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Jing CaiCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9207-7907
Ethan Trevor SuwandiDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Derk JoesterDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.ORCID https://orcid.org/0000-0002-9663-3309
Natalie C KegulianCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Edwin SarkisiansCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Marziyeh AghazadehCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Simon WebsterCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.
Janet Moradian-OldakCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-5777-6297

Funding

MATRIX-BASED MINERAL (MBM) ENAMEL BIOMIMETICSR01DE013414 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Janet Oldak · 2001 to 2026
$8.6M
A Peptide-Based Biomineralization Strategy for Tooth RepairR01DE027632 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OLDAK, JANET · 2019 to 2022
$1.6M
DOCTORAL AND POST-DOCTORAL TRAINING IN CRANIOFACIAL BIOLOGYR90DE022528 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAINE, MICHAEL LANSDELL · 2011 to 2025
$1.3M
Enamel atlas: systems-level amelogenesis tools at multiple scalesUG3DE028872 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOESTER, DERK, KLEIN, OPHIR D · 2019 to 2020
$1.1M
NIDCR NIH HHS R01 DE013414NIDCR NIH HHS R01 DE027632NIDCR NIH HHS R90 DE022528NIDCR NIH HHS UG3 DE028872
6 · The paper itself

Abstract

Ameloblastin (Ambn) is a tooth-specific multifunctional protein crucial for enamel biomineralization and its prismatic structure. To examine the function of the evolutionarily conserved cell-binding Ambn amphipathic helix (AH) motif, we deleted the hydrophobic residues within Ambn AH motif in genetically engineered mice. Enamel in the homozygous (

Identifiers

PMID41646298
PMCPMC12869563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.