Evidence map›Paper›PMID 41646295›Full record

ArticleResearch square2026

Xiu-Qi Tian, Dakota N Paine, Alejandro Marín López, Dong Feng, Shanshan Du, Sukanya Narasimhan, Saravanan Thangamani, Erol Fikrig

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiu-Qi TianSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06510, USA.ORCID 0009-0000-6091-454X
Dakota N PaineSUNY Center for Vector-Borne Diseases, Department of Microbiology and Immunology, Institute for Global Health and Translational Science, Upstate Medical University, Syracuse, NY 13210, USA.
Alejandro Marín LópezCenter of Research in Animal Health (CISA-INIA, CSIC), Algete-El Casar road, km. 8.1, Madrid 28130, Spain.
Dong FengSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06510, USA.
Shanshan DuSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06510, USA.
Sukanya NarasimhanSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06510, USA.ORCID 0000-0003-0396-8757
Saravanan ThangamaniSUNY Center for Vector-Borne Diseases, Department of Microbiology and Immunology, Institute for Global Health and Translational Science, Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0000-0002-4269-5993
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06510, USA.ORCID 0000-0002-5884-6047

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033
6 · The paper itself

Abstract

The stimulator of interferon genes (STING) is a central adaptor in antiviral signaling, but its role in vectors that transmit human and animal pathogens remains poorly understood. Here, we show that the tick STING homolog, tSTING, facilitates Powassan virus (POWV) infection in

Identifiers

PMID41646295
PMCPMC12869556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.