Evidence map›Paper›PMID 41646294›Full record

ArticleResearch square2026

PTPN11-Related Noonan Syndrome Predisposes to Multifocal Low-Grade CNS Tumors Harboring FGFR1 Variants.

Gary Kohanbash, Scott Ryall, Sam E Gary, Lindsey M Hoffman, Robert Siddaway, Anne E Bendel, Karen W Gripp, Andrew W Walter, Jordan R Hansford, Amy A Smith and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Gary KohanbashUniversity of Pittsburgh.
Scott RyallHospital for Sick Children.
Sam E GaryUniversity of Pittsburgh.
Lindsey M HoffmanChildren's Hospital Colorado.
Robert SiddawayHospital for Sick Children.
Anne E BendelChildren's Minnesota.
Karen W GrippAlfred I. duPont Hospital for Children.
Andrew W WalterAlfred I. duPont Hospital for Children.
Jordan R HansfordRoyal Children's Hospital.
Amy A SmithArnold Palmer Hospital for Children.
Hong WangUniversity of Pittsburgh.
John M SkaugenUniversity of Pittsburgh.
Uri TaboriHospital for Sick Children.
Cynthia E HawkinsUniversity of Toronto.
Alberto BroniscerChildren's Hospital of Pittsburgh.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

Purpose: To characterize the clinical, radiological, and molecular characteristics of CNS tumors associated with Noonan syndrome (NS) and other non-Neurofibromatosis type 1 RASopathies. Methods: Twenty-four patients with concern for NS underwent clinical and central radiological review in this multi-institutional study. Whole-exome sequencing, RNA sequencing, and methylation analyses of peripheral blood and/or tumor specimens were performed. Results: Nineteen (79%) of 24 participants had NS, 17/19 (89%) of which had a germline Conclusion:

Indexed as

Brain tumorFGFR1gliomaNoonan syndromePTPN11

Identifiers

PMID41646294
PMCPMC12869574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.