Evidence map›Paper›PMID 41646291›Full record

ArticleResearch square2026

Genome-wide profiling of RNA 2'-O-methylation in neurons and identification of orphan snoRNA targets.

Gordon Carmichael, Xuan Ye, Yaling Liu, Yinzhou Zhu, Saran Alshawi, Brittany Elliott, Christopher Holley, Jean-Denis Beaudoin, Brenton R Graveley

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gordon CarmichaelUniversity of Connecticut Health Center.ORCID 0000-0002-0379-6580
Xuan YeUniversity of Connecticut Health Center.
Yaling LiuUniversity of Connecticut Health Center.
Yinzhou ZhuDuke University School of Medicine.ORCID 0000-0003-0043-1321
Saran AlshawiUniversity of Connecticut Health Center.
Brittany ElliottDuke University.ORCID 0000-0001-5907-1231
Christopher HolleyDuke University.ORCID 0000-0002-2870-3352
Jean-Denis BeaudoinUniversity of Connecticut Health Center.
Brenton R GraveleyUniversity of Connecticut Health Center.ORCID 0000-0001-5777-5892

Funding

Genomic Analysis of Nucleic Acid TransactionsR35GM118140 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2016 to 2025
$6.8M
Molecular underpinnings of Prader-Willi syndromeR01HD099975 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CARMICHAEL, GORDON G, COTNEY, JUSTIN LEE · 2019 to 2023
$2.9M
Regulatory roles of the epitranscriptome and RNA structurome during vertebrate developmentR35GM146883 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Jean-Denis Beaudoin · 2022 to 2026
$2.1M
SnoRNA-guided modifications of mRNAR01GM135383 · NIGMS · DUKE UNIVERSITY · PI HOLLEY, CHRISTOPHER LEE · 2020 to 2023
$1.3M
Elucidating the role of FBLL1 in ribosome function during neuronal differentiationF31HD114435 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ALSHAWI, SARAH ANN · 2024 to 2025
$92k
NICHD NIH HHS F31 HD114435NICHD NIH HHS R01 HD099975NIGMS NIH HHS R01 GM135383NIGMS NIH HHS R35 GM118140NIGMS NIH HHS R35 GM146883
6 · The paper itself

Abstract

We have compared genome-wide patterns of RNA 2'-

Identifiers

PMID41646291
PMCPMC12869633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.