Evidence map›Paper›PMID 41646279›Full record

ArticleESMO gastrointestinal oncology2025

A J Muñoz Martín, F Castet, J Soto Alsar, J Adeva, P Peinado, B Graña, I Alés Díaz, R M Rodríguez-Alonso, M Lobo de Mena, R Vera and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in ESMO gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711211 (A Descriptive, Multicentre, Observational Epidemiological Study on Digestive Tumours), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06711211 recruitingnot on this map

A Descriptive, Multicentre, Observational Epidemiological Study on Digestive Tumours

Typeobservational_patient_registrySponsorSpanish Cooperative Group for the Treatment of Digestive Tumours (TTD)Ran2020 to 2030Enrolled20,000ConditionsDigestive Cancers, Bile Duct Cancer, Hepatocellular Cancer (HCC), Colorectal Cancer (CRC)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

A J Muñoz MartínMedical Oncology Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
F CastetMedical Oncology Department, Vall d'Hebron University Hospital, Vall d´Hebrón Institute of Oncology (VHIO), Barcelona, Spain.
J Soto AlsarMedical Oncology Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
J AdevaMedical Oncology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Universidad Complutense de Madrid, Madrid, Spain.
P PeinadoDepartment of Medical Oncology, Centro Integral Oncológico Clara Campal (HM CIOCC Madrid), Hospital Universitario HM Sanchinarro, HM Hospitales, Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain.
B GrañaMedical Oncology Department, Pontevedra University Hospital, Galicia Sur Health Research Institute (IISGS), Pontevedra, Spain.
I Alés DíazMedical Oncology Department, UGCI Medical Oncology, Malaga University Regional Hospital, Malaga, Spain.
R M Rodríguez-AlonsoDepartment of Medical Oncology, IMIBIC, Córdoba University, CIBERONC, Reina Sofia University Hospital, Córdoba, Spain.
M Lobo de MenaDepartment of Medical Oncology Consorcio Hospital General Universitario de Valencia, Valencia, Spain.
R VeraMedical Oncology Department, Hospital Universitario de Navarra, Pamplona, Spain.
I Ruiz de MenaSpanish Cooperative Group for the Treatment of Digestive Tumors, Madrid, Spain.
S AguilarVHIOTECA & Prescreening Program, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
S VegaMedical Oncology Department, Vall d'Hebron University Hospital, Vall d´Hebrón Institute of Oncology (VHIO), Barcelona, Spain.
L Ortega MoránMedical Oncology Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
T MacarullaMedical Oncology Department, Vall d'Hebron University Hospital, Vall d´Hebrón Institute of Oncology (VHIO), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antagonist of mouse double minute 2 homolog ( Materials and methods: A real-world cohort of patients diagnosed with BTC (1 January 2017 to 31 December 2022) was evaluated (RETUD NCT06711211). Next-generation sequencing (NGS) testing was carried out. Demographic and clinical characteristics, molecular profile, treatments, and effectiveness [overall response rate (ORR) and survival outcomes] were assessed. Progression-free survival (PFS), overall survival (OS), and ORR were estimated for patients receiving first-line therapy, using the Kaplan-Meier method. Descriptive analyses were used to assess demographic, clinical, and molecular features. Results: A total of 301 patients were included. Conclusions: Incidence of

Indexed as

biliary tract cancerMDM2 amplificationreal-world dataRETUD registrySpain

Identifiers

PMID41646279
PMCPMC12836494

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.