ArticleFrontiers in pharmacology2026
Mechanism of Yiqi Huoxue Granule in promoting angiogenesis of skin lesion tissue by increasing CSF2 to reduce mesenchymal stem cell apoptosis.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the effect and mechanism of the Yiqi Huoxue Granule in improving the survival of mesenchymal stem cells (MSCs) induced by hypoxia and promoting angiogenesis in damaged tissues. Methods: Animal experiments: A rat skin injury model was established. The skin healing degrees were compared among the model group, MSC group, and Yiqi Huoxue Granule group and Yiqi Huoxue Granule combined with MSC group. The intensity of DIR-labeled MSCs was observed by frozen section, and the expression of CD31 in tissues was detected by immunofluorescence. Cell experiments: A hypoxic MSC model was constructed. The effect of the Yiqi Huoxue Granule on the viability of hypoxic MSCs was detected by CCK8. Flow cytometry was used to observe the apoptosis rate of MSCs. The effect of Yiqi Huoxue Granule on tube formation of MSCs was observed by tube formation assay. Differentially expressed genes were analyzed using transcriptomics and verified through RT-PCR. Key factors were analyzed by PPI. Results: DIR-labeled MSCs showed that at a concentration of 50 μM, the count of red spots in MSCs significantly increased compared to 12.5 μM and 25 μM (P < 0.01 or 0.001), and there was no statistical difference in cell viability compared to the 12.5 μM and 25 μM groups (P > 0.05), thus 50 μM DIR was selected for Conclusion: This research offers a novel perspective for MSC apoptosis using Yiqi Huoxue Granule. Yiqi Huoxue Granule promotes the survival of MSCs under hypoxia and in damaged skin tissue, improves angiogenesis in damaged skin tissue, accelerates skin wound healing, and is closely related to the elevation of Csf2.
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