ReviewFrontiers in nutrition2026
Maternal nutritional imbalance during pregnancy and the development of fetal-origin cardiovascular diseases.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Placental lipid handling, growth and inflammatory pathways are modified by a maternal Mediterranean diet.Scientific reports · 2026Trial
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prenatal period is a critical window for cardiovascular development in offspring. Accumulating evidence demonstrates that maternal nutritional imbalances during pregnancy-encompassing undernutrition, overnutrition, and specific nutrient deficiencies-elicit adverse adaptations in fetal vascular systems, thereby predisposing offspring to cardiovascular disease (CVD) in later life. This review synthesizes current knowledge on the impact of macronutrient (e.g., high-sugar, high-fat diets) and micronutrient (e.g., vitamin D, folate) imbalances, as well as exposures to alcohol and caffeine, on offspring cardiovascular health. Key mechanisms such as epigenetic regulation (e.g., DNA methylation, histone modifications), oxidative stress, and endothelial dysfunction are discussed. Furthermore, we highlight future research directions and potential early nutritional interventions aimed at mitigating long-term cardiovascular risks and breaking the cycle of intergenerational metabolic disease. By integrating mechanistic insights and epidemiological evidence, this review underscores the importance of optimizing maternal nutrition as a pivotal public health strategy for preventing offspring CVD.
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