Demonstration of feasibility and technique of transesophageal endoscopic epicardial access in a porcine model.

Zachary N Weitzner, Steven Cha, Ronald Challita, Olujimi Ajijola, Shumpei Mori, Kalyanam Shivkumar, Erik Dutson, Alireza Sedarat

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Article in iGIE : innovation, investigation and insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

8 authors.

Zachary N WeitznerDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Steven ChaDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Ronald ChallitaDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Olujimi AjijolaDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Shumpei MoriDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Kalyanam ShivkumarDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Erik DutsonDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Alireza SedaratDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Peroral endoscopic myotomy uses a submucosal tunnel that staggers the esophageal mucosotomy and myotomy, allowing minimally invasive interventions in the esophagus to treat achalasia. Our goal was to assess the feasibility of this method to access the mediastinum to perform endoscopic epicardial access and pericardial window in a porcine model. Methods: Experiments were conducted to assess the feasibility of this procedure. Commonly available ERCP and EUS instruments were used to show epicardial access under both direct transesophageal mediastinoscopic visualization and EUS guidance. Results: In experiments, we successfully placed catheters in the pericardial space without hemodynamic instability or adverse events. A pericardial window was performed in other experiments, draining the instilled simulated pericardial effusion. Conclusion: Transesophageal epicardial access and pericardial window seemed to be feasible and well tolerated in a porcine model, indicating the possibility of expanding mediastinal procedures conducted with endoscopy in the future.

Identifiers

PMID41646068

DOI10.1016/j.igie.2023.10.008

PMCPMC12850758

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