Evidence map›Paper›PMID 41646064›Full record

ArticleiGIE : innovation, investigation and insights2023

Endoscopic resection alone as a potential treatment method for low-risk deep invasive T1 colorectal cancer.

Yuta Kouyama, Shin-Ei Kudo, Katsuro Ichimasa, Shingo Matsudaira, Yushi Ogawa, Kenichi Mochizuki, Yuki Takashina, Yuta Sato, Tatsuya Sakurai, Yasuharu Maeda and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iGIE : innovation, investigation and insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuta KouyamaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Shin-Ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Katsuro IchimasaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Shingo MatsudairaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yushi OgawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Kenichi MochizukiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yuki TakashinaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yuta SatoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Tatsuya SakuraiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yasuharu MaedaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Hiroki NakamuraDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Masashi MisawaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Yuichi MoriDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Toyoki KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Takemasa HayashiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Kunihiko WakamuraDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Tetsuo NemotoDepartment of Diagnostic Pathology, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa, Japan.
Toshiyuki BabaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Hideyuki MiyachiDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Although T1b (deep submucosal invasion) is described as an indication of surgical resection with lymph node dissection for T1 colorectal cancer (CRC) in current guidelines, it reportedly has a weaker correlation to the lymph node metastasis (LNM) than other risk factors (lymphovascular invasion, poorly differentiated or mucinous adenocarcinoma, and tumor budding). "Low-risk T1b" CRC, which is defined as a lesion with only T1b and no other risk factors, may not require additional surgical resection. The aim of this study was to evaluate the necessity of surgeries in patients with low-risk T1b CRC from the point of the risk of LNM, recurrence, and long-term outcome. Methods: From April 2001 to March 2019, a total of 1271 T1 CRCs were resected. Invasion depth and tumor budding were diagnosed according to the Japanese guideline, lymphovascular invasion was evaluated with special staining and immunostaining, and histologic grade was diagnosed by the highest differentiation. A total of 354 patients with low-risk T1b CRC were then analyzed. Among these, 105 patients were resected endoscopically without surgical resection (ER-alone group), and 249 patients were resected surgically (SR group). The rate of LNM, the cumulative recurrence, and overall survival (OS) were examined in each group. Results: No LNM was observed in either the ER-alone group (0%; 95% CI, 0-4.2) or the SR group (0%; 95% CI, 0-1.8). Five-year cumulative recurrence rate was 0% (95% CI, 0-9) in the ER-alone group and 0% (95% CI, 0%-3%) in the SR group. The 5-year OS rate was 93% (95% CI, 90-96) in the ER-alone group and 95% (95% CI, 93-96) in the SR group ( Conclusions: ER alone without SR could be a potential treatment method for patients with low-risk T1b CRC.

Identifiers

PMID41646064
PMCPMC12850749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.