ArticleiGIE : innovation, investigation and insights2023
Endoscopic versus surgical therapies for GERD: a systematic review and network meta-analysis.
Article in iGIE : innovation, investigation and insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Clinical Outcomes and Quality of Life after Laparoscopic Nissen Fundoplication for Refractory Gastroesophageal Reflux Disease: A Prospective Cohort Study from Vietnam.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026Article
- Targeted Endoscopic Therapies for Gastro-Esophageal Reflux Disease (GERD): A Narrative Review.Journal of personalized medicine · 2026Review
- Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough.Surgical endoscopy · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: The objective of our study was to compare the outcomes of endoscopic and surgical therapies for GERD using a network meta-analysis. Methods: Only randomized control trials with adult patients were included in the study. Radiofrequency energy (RFe) delivery, transoral incisionless fundoplication (TIF), magnetic sphincter augmentation (MSA), and Nissen, Toupet, and anterior fundoplication were studied. Outcomes of interest were GERD health-related quality of life (GERD-HRQL), proton pump inhibitor (PPI) use, presence of esophagitis, percentage of time with pH <4 on 24-hour esophageal pH monitoring (% time pH <4), and lower esophageal sphincter pressure (LESP) at ≤12-month follow-up. Results: Twenty-seven studies (3515 patients) were included. GERD-HRQL scores for TIF and RFe were not significantly different (mean difference [MD], -3.81; 95% confidence interval [CI], -10.65 to 3.04) but were significantly better than PPI use alone. No significant differences occurred between endoscopic and surgical procedures in terms of esophagitis, % time pH <4, or cessation of PPI use. Regarding LESP, RFe was inferior to TIF (MD, -9.23; 95% CI, -13.89 to -4.58) and to Nissen (MD, -9.00; 95% CI, -14.55 to -3.45), Toupet (MD, -6.83; 95% CI, -12.50 to -1.55), and anterior (MD, -7.5; 95% CI, -13.35 to -1.71) fundoplication. LESP was comparable for endoscopic and surgical fundoplication. Conclusions: TIF did not demonstrate significantly different short-term outcomes compared with surgical fundoplication procedures. TIF should be considered on a case-by-case basis in patients who do not want surgery or are not surgical candidates. RFe is inferior to TIF and surgical fundoplication. MSA requires more randomized control trial data.
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Registered trials
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