Evidence map›Paper›PMID 41645854›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross-Coupling.

Nils Kurig, David A Cagan, Kaid C Harper, Yu Kawamata, Donna G Blackmond, Phil S Baran

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Recyclable dual Z-scheme perovskite/g-CNature communications · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nils KurigDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-0717-1964
David A CaganDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-4719-2789
Kaid C HarperAbbvie Process Research and Development, North Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3894-4851
Yu KawamataDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-5515-9612
Donna G BlackmondDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-9829-8375
Phil S BaranDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-9193-9053

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
Accelerating Discovery by Merging Kinetics with Data Science Methods in Catalytic Organic ReactionsR35GM158320 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Donna G Blackmond · 2025 to 2026
$1.0M
National Academy of Sciences Leopoldina LPDS 2023-08National Science Foundation NSF 2500003NIGMS NIH HHS R35 GM118176NIGMS NIH HHS R35 GM158320NIH HHS NIH1R35GM158320-01NIH HHS NIHGM-118176
6 · The paper itself

Abstract

Reductive cross-couplings have emerged as a powerful strategy for forging C-C bonds directly from electrophiles, circumventing the need for preformed organometallic reagents, yet they often suffer from limitations associated with heterogeneous reductants like Zn (e.g., poor reproducibility and scalability) or costly homogeneous alternatives such as TDAE. Inspired by prior explorations of hydrazide chemistry, we disclose arylhydrazines as inexpensive, readily available homogeneous sacrificial reductants that enable Ni-catalyzed sp

Indexed as

cross‐couplingNi‐catalysisreaction calorimetryreaction mechanismsscale‐up

Identifiers

PMID41645854
PMCPMC12991040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.