Evidence map›Paper›PMID 41645766›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Design, synthesis and biological evaluation of donepezil-safinamide hybrids as dual AChE and MAO-B inhibitor for Alzheimer's disease treatment.

Wei Li, Yan Guo, Xiaoli Wang, Chunyan Yang, Jiang Zhu, Zhongcheng Cao

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei LiSchool of Pharmacy, North Sichuan Medical College, Nanchong, China.
Yan GuoSchool of Pharmacy, North Sichuan Medical College, Nanchong, China.
Xiaoli WangSchool of Pharmacy, North Sichuan Medical College, Nanchong, China.
Chunyan YangSchool of Pharmacy, North Sichuan Medical College, Nanchong, China.
Jiang ZhuSichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China.
Zhongcheng CaoSchool of Pharmacy, North Sichuan Medical College, Nanchong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) still lacks therapies that definitively halt its progression. Dual AChE/MAO-B inhibitors offer a promising strategy to address both symptoms and pathology. Here, we designed and synthesised a series of donepezil-safinamide hybrids. The optimised compound

Indexed as

Alzheimer DiseaseBenzylaminesCholinesterase InhibitorsDonepezilMonoamine Oxidase InhibitorsAlanineAnimalsBlood-Brain BarrierDrug DesignHumansMaleMiceMice, Inbred C57BLMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureAlanineBenzylaminesCholinesterase InhibitorsDonepezilMonoamine Oxidase InhibitorssafinamideAChE/MAO-B dual inhibitorAlzheimer’s diseasedonepezil-safinamide hybridsneuroprotection

Identifiers

PMID41645766
PMCPMC12885038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.