ArticleBrain and behavior2026
Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model.Brain and behavior · 2026Article
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14 authors.
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Abstract
BACKGROUND AND
aimChanges in neural plasticity crucially modulate functional recovery after central nerve injury. To describe morphological peripheral nerve injury-related changes, we comprehensively elucidated post-sciatic nerve transection (post-SNT) plasticity changes in the lumbar spinal corticospinal tract (CST), motor neurons, and cholinergic interneurons (CINs).
methodsIn a rat SNT model, we compared post-SNT changes in lumbar spinal cord plasticity at 2, 4, and 6 weeks with those in the Sham group. Using neural tracers and immunohistochemistry, we labeled and analyzed the CST axonal number and volume, motor neuron cell-body volume and synaptic inputs, and cholinergic interneuron (CIN) (medial and lateral, based on the distance from the central canal) number and synaptic inputs.
resultsCompared to the Sham group, the SNT groups showed no significant post-SNT changes in CST axonal number and volume. Motor neuron cell-body volume decreased by 29% at 6 weeks post-SNT, and vesicular glutamate transporter 1 (vGlut1) and vesicular acetylcholine transporter (vAchT) synaptic inputs decreased by 82-93% and 27-42%, respectively, from 2 weeks post-SNT onward. From 2 weeks post-SNT onward, cell numbers were maintained, although vGlut1 synaptic inputs increased by 98%-68% in lateral CINs. At 6 weeks post-SNT, a 44% reduction in cell numbers and a simultaneous 107% increase in vGlut1 synaptic inputs were noted in medial CINs.
conclusionFollowing SNT, although CST axonal numbers remained unchanged, plasticity changes were observed in motor neurons and in CINs. CINs exhibited distinct plasticity changes depending on their localization.
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