ArticleEuropean journal of medical research2026
Association of the LncRNA TINCR rs2288947 polymorphism with survival outcomes in severe pneumonia among Han Chinese children.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe identification of reliable biomarkers for clinical diagnosis and prognostic evaluation of severe pneumonia remains challenging. Long non-coding RNA (lncRNA) TINCR, along with its genetic variant rs2288947, has been suggested to play a role in the pathophysiology of severe pneumonia. This study aimed to examine the relationship between the rs2288947 polymorphism and the risk of developing severe pneumonia, the degree of inflammatory response, and 28-day outcomes in pediatric patients.
methodsA total of 355 children diagnosed with severe pneumonia and 326 healthy controls were included. Plasma lncRNA TINCR expression was measured via qRT-PCR, and rs2288947 genotyping was performed using the TaqMan assay. 28-day survival based on Kaplan-Meier analysis were assessed. Multivariate Cox regression was employed to determine independent prognostic factors.
resultsExpression of lncRNA TINCR was significantly reduced in the severe pneumonia group compared to controls. At the rs2288947 locus, the presence of the A allele was correlated with downregulated expression of the lncRNA TINCR. Carriers of the GA or AA genotypes consistently demonstrated decreased lncRNA TINCR expression levels. The AA genotype and the A allele of rs2288947 were associated with an elevated risk of severe pneumonia. Patients carrying the GA + AA genotypes showed higher levels of inflammatory markers (WBC, CRP, PCT, neutrophils) and a lower 28-day survival rate. The rs2288947 polymorphism was identified as an independent prognostic factor.
conclusionsThe rs2288947 variant may represent a useful biomarker for evaluating susceptibility and predicting prognosis in pediatric severe pneumonia.
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