Evidence map›Paper›PMID 41645204›Full record

ArticleHealth and quality of life outcomes2026

Quality of life scores using SF-12 and SF-36v2 questionnaires for patients with multidrug-resistant tuberculosis in Vietnam.

Nguyen Thi Lien Ha, Nguyen Binh Hoa, Manisha Yapa, Nguyen Thu Anh, Qingbin Li, Vu Hai Dang, Greg J Fox, Vu Quoc Dat

Abstract read
In one paragraph

Article in Health and quality of life outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Nguyen Thi Lien HaDepartment of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.
Nguyen Binh HoaNational Lung Hospital, Hanoi, Vietnam.
Manisha YapaFaculty of Medicine and Health, The University of Sydney, NSW, Australia.
Nguyen Thu AnhFaculty of Medicine and Health, The University of Sydney, NSW, Australia.
Qingbin LiFaculty of Medicine and Health, The University of Sydney, NSW, Australia.
Vu Hai DangThe University of Sydney Viet Nam Institute, Ho Chi Minh city, Vietnam.
Greg J FoxFaculty of Medicine and Health, The University of Sydney, NSW, Australia.
Vu Quoc DatDepartment of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam. vu.dat@sydney.edu.au.ORCID http://orcid.org/0000-0002-5904-5970

Funding

National Foundation for Science and Technology Development NHMRC.108.02-2018.0National Health and Medical Research Council NHMRC, APP 1157643
6 · The paper itself

Abstract

backgroundThe health-related quality of life (QoL) assessed by the 12-item Short Form (SF-12) offers a time-efficient alternative to the 36-item version 2 (SF-36 v2). This study aimed to compare the performance of SF-12 and SF-36 v2 among patients with rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) in Vietnam.

methodsA cross-sectional survey was conducted among RR/MDR-TB patients treated in seven provinces between October 2020 and March 2023. Participants completed the SF-36 v2 questionnaire at enrollment. Physical (PCS) and mental component summary (MCS) scores were compared between SF-12 and SF-36 v2. Linear regression assessed the ability of PCS-12 and MCS-12 to predict PCS-36 and MCS-36. Discriminative ability was assessed via receiver operating characteristic (ROC) curves.

resultsThis study included 565 participants with a median age of 45.4 years (IQR 44.2–46.5) and a male proportion of 71.7%. 64.1% (362/565) had PCS-36 and 88.3% (499/565) had MCS-36 scores well below and below population norms. The mean scores of PCS-12 and MCS-12 were higher than those of PCS-36 (45.1; 95% CI 44.1–46.1 vs. 43.6; 95% CI 43.1–44.1), and MCS-36 (45.2; 95% CI 43.8–46.6 vs. 34.6; 95% CI 33.9–35.4; p < 0.001), respectively. The Intraclass Correlation Coefficients (ICCs) between PCS and MCS scores of SF-12 and SF-36 v2 were 0.6 (95% CI: 0.5–0.6) and 0.5 (95% CI: 0.4–0.5) respectively. The AUC values for comparing the performance of PCS and MCS of two scales were 0.89 and 0.99, respectively. We found the excellent linear correlation between PCS-12 and PCS-36 (r = 0.8; p < 0.001) and between MCS-12 and MCS-36 scores (r = 0.9; p < 0.001).

conclusionSF-12 had moderate correlation to SF-36 v2 for QoL assessment in RR/MDR-TB patients, though it tends to overestimate QoL in older and male individuals.

Indexed as

Quality of LifeTuberculosis, Multidrug-ResistantAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedROC CurveSurveys and QuestionnairesVietnamMulti-drug resistant tuberculosisQuality of lifeShort-Form 12Short-Form 36

Identifiers

PMID41645204
PMCPMC12973597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.