ArticleBMC pulmonary medicine2026
Clinical, laboratory, and MRI features differentiating tuberculous and pyogenic spondylodiscitis: a propensity score-matched analysis.
Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part II: MRI/CT Features, Prediction Models, and the Role of PET/CT-A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part I-Epidemiology, Clinical Features, Laboratory Markers, and Tissue-Based Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical and imaging factors associated with paraplegia at presentation in thoracic spinal tuberculosis.International orthopaedics · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferentiating tuberculous spondylodiscitis (TS) from pyogenic spondylodiscitis (PS) is challenging due to overlapping clinical and radiological features. Early and accurate diagnosis is crucial for appropriate management. This study aimed to identify clinical, laboratory, and MRI parameters that may assist in the early differentiation of TS from PS.
methodsThis retrospective study included 76 adult patients diagnosed with TS (n = 21) or PS (n = 55) between January 2023 and July 2025. Clinical, laboratory, and MRI findings were compared between groups. To reduce selection bias, propensity score matching (PSM) was applied based on age, sex, and comorbidities. Variables showing significant differences in univariate analyses were entered into a multivariate logistic regression model to determine independent predictors of TS.
resultsBefore and after PSM, the symptom duration was significantly longer in TS. Inflammatory markers (WBC, neutrophil count, ESR, and CRP) were higher in patients with PS. MRI revealed that thoracic involvement and vertebral body destruction greater than 50% were significantly associated with TS both before and after PSM and remained independent predictors in multivariate analysis (p = 0.048 and p = 0.013, respectively).
conclusionThoracic vertebral involvement and vertebral destruction exceeding 50% are independent predictors of tuberculous spondylodiscitis, providing valuable guidance for early and accurate differentiation from pyogenic infection.
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