Evidence map›Paper›PMID 41645054›Full record

ArticleBMC genomics2026

Gut microbiota response to Enterocytozoon bieneusi infection in wild rodents: enhanced vitamin B and K

Xiao-Xuan Zhang, He Zhang, Ji-Xin Zhao, Hai-Long Yu, Chun-Ren Wang, Kai-Meng Shang, Yong-Jie Wei, Ya Qin, Jian-Ming Li, Zi-Yu Zhao and 4 more

Abstract read
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiao-Xuan Zhang *College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
He Zhang *State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang Province, People's Republic of China.
Ji-Xin ZhaoCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
Hai-Long YuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
Chun-Ren WangCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, People's Republic of China.
Kai-Meng ShangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
Yong-Jie WeiCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
Ya QinCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China.
Jian-Ming LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin Province, People's Republic of China.
Zi-Yu ZhaoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin Province, People's Republic of China.
Chang-You XiaState Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang Province, People's Republic of China. xiachangyou@caas.cn.
Bei-Ni ChenCollege of Life Sciences, Changchun Sci-Tech University, Shuangyang, Jilin Province, People's Republic of China.
Hany M ElsheikhaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, UK. Hany.Elsheikha@nottingham.ac.uk.
He MaCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, People's Republic of China. mahe@qau.edu.cn.

Funding

the Horizontal Project of Qingdao Agricultural University Grant No. 667/2424025the National Key R&D Program of China 2022YFF0710503the National Natural Science Foundation of China Grant No. 32170538the National Natural Science Foundation of China-Youth Science Fund 32500449the Natural Science Foundation of Heilongjiang Province ZD2022C006
6 · The paper itself

Abstract

Enterocytozoon bieneusi (E. bieneusi) is a pathogenic microsporidian that affects immunocompromised individuals, including those with HIV, and represents a major cause of diarrhea. It can severely impact human health, causing gastrointestinal disease, nutritional deficits, and life-threatening complications. However, the microbial mechanisms by which E. bieneusi affects host nutrition are not well understood. Wild rodents have long been considered valuable models for studying human diseases due to similarities in gut microbiota dynamics and immune responses, making them particularly relevant for investigating parasitic infections. Here, we assembled a comprehensive catalog of 9,929 non-redundant microbial genomes from wild rodent gut metagenomes and evaluated their potential for B vitamins and vitamin K

Indexed as

Biosynthetic PathwaysEnterocytozoonGastrointestinal MicrobiomeMicrosporidiosisRodentiaVitamin B ComplexAnimalsAnimals, WildMetagenomeVitamin B ComplexComparative GenomicsEnterocytozoon bieneusiGut MicrobiotaHost-Microbe InteractionsVitamin SynthesisWild Rodents

Identifiers

PMID41645054
PMCPMC12973552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.