In one paragraphArticle in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Naoki KiharaDepartment of Neurology, Tokushima University Hospital, Tokushima, Japan.
Koji FujitaDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0003-4789-1579 Konoka TachibanaDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0009-0000-4545-563X Yusuke OsakiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0001-6588-5442 Nazere KeyoumuDepartment of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0009-0000-4318-6237 Yuki KuwanoDepartment of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0009-0008-5473-5068 Nobutoshi MorimotoDepartment of Neurology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
Suzuran SaitoDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Eriko KoshimizuDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0001-9947-3315 Yoichi OtomiDepartment of Radiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0002-8960-3662 Kenji IshibashiDiagnostic Neuroimaging Research, Research Team for Neuroimaging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.ORCID 0000-0002-4590-7146 Masafumi HaradaDepartment of Radiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0003-0958-1094 Naomichi MatsumotoDepartment of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan.ORCID 0000-0001-9846-6500 Hiroyuki MorinoDepartment of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0002-5190-3547 Yuishin IzumiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0002-3048-9041 Funding
Japan Agency for Medical Research and Development JP23re0122001Japan Agency for Medical Research and Development JP25dk0207066Japan Agency for Medical Research and Development JP25ek0109617Japan Agency for Medical Research and Development JP25ek0109648Japan Agency for Medical Research and Development JP25ek0109674Japan Agency for Medical Research and Development JP25ek0109677Japan Agency for Medical Research and Development JP25ek0109760Japan Society for the Promotion of Science JP23K27520Japan Society for the Promotion of Science JP24K02230Japan Society for the Promotion of Science JP25K19028MHLW Research on rare and intractable diseases Program JPMH23FC1008Naito FoundationTakeda Science Foundation
6 · The paper itselfAbstract
We report a 58-year-old woman with a novel splice-site variant in the TANK-binding kinase 1 (TBK1:c.993-2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and prosopagnosia represented the earliest manifestation of rtvFTD. Molecular analysis revealed reduced levels of correctly spliced TBK1 transcripts, consistent with haploinsufficiency. Given the shared involvement of TDP-43 pathology in both PLS and rtvFTD, this case indicates TBK1 dysfunction as a fundamental genetic factor underlying the coexistence of these phenotypes, underscoring the clinical value of early neuroimaging and genetic evaluation.
Indexed as
Frontotemporal DementiaMotor Neuron DiseaseProtein Serine-Threonine KinasesFemaleHumansMiddle AgedProtein Serine-Threonine KinasesTBK1 protein, humanfrontotemporal dementiamotor neuron diseaseprimary lateral sclerosisTBK1TDP‐43
Identifiers
PMID41645024
PMCPMC13161887
What OpenQuestion holds
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LicenceCC BY
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