Evidence map›Paper›PMID 41644947›Full record

ArticleNature communications2026

Closed-form feedback-free learning with forward projection.

Robert O'Shea, Bipin Rajendran

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert O'SheaCentre for Intelligent Information Processing Systems, Department of Engineering, King's College London, London, UK. k1930297@kcl.ac.uk.ORCID http://orcid.org/0000-0003-4983-7912
Bipin RajendranCentre for Intelligent Information Processing Systems, Department of Engineering, King's College London, London, UK. bipin.rajendran@kcl.ac.uk.ORCID http://orcid.org/0000-0002-2960-6909

Funding

RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/X011356/1
6 · The paper itself

Abstract

State-of-the-art backpropagation-free learning methods employ local error feedback to direct iterative optimisation via gradient descent. Here, we examine the more restrictive setting where retrograde communication from neuronal outputs is unavailable for pre-synaptic weight optimisation. We propose Forward Projection (FP), a randomised closed-form training method requiring only a single forward pass over the dataset without retrograde communication. FP generates target values for pre-activation membrane potentials through randomised nonlinear projections of pre-synaptic inputs and labels. Local loss functions are optimised using closed-form regression without feedback from downstream layers. A key advantage is interpretability: membrane potentials in FP-trained networks encode information interpretable layer-wise as label predictions. Across several biomedical datasets, FP achieves generalisation comparable to gradient descent-based local learning methods while requiring only a single forward propagation step, yielding significant training speedup. In few-shot learning tasks, FP produces more generalisable models than backpropagation-optimised alternatives, with local interpretation functions successfully identifying clinically salient diagnostic features.

Identifiers

PMID41644947
PMCPMC12988171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.