Evidence map›Paper›PMID 41644862›Full record

ArticlePlant cell reports2026

Overexpression of cytochrome P450 CYP710A8B likely contributing resistance to fenoxaprop-P-ethyl in Avena fatua L. from China.

Pei Zhang, Yuqing Liu, Xinyang Yuan, Junchuan Song, Runqiang Liu, Hongliang Wang

Abstract read
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Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pei ZhangSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China. zhangpei0519@hist.edu.cn.
Yuqing LiuSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Xinyang YuanSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Junchuan SongSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Runqiang LiuSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Hongliang WangSchool of Plant Protection and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, China. whll@hist.edu.cn.

Funding

High-level Talent Introduction Project of Henan Institute of Science and Technology 2018024Key Research and Development Project of Henan Province 241111111700Postdoctoral research project of Henan Province HN2022121
6 · The paper itself

Abstract

Avena fatua L. is a major grass weed infesting wheat fields worldwide, with the ACCase-inhibiting herbicide fenoxaprop-P-ethyl serving as the primary chemical control agent. However, prolonged and widespread use has resulted in the evolution of resistance in A. fatua, posing a serious threat to effective weed management in wheat production. This study investigates the resistance level and elucidates the underlying mechanisms in a fenoxaprop-P-ethyl-resistant A. fatua population (HZXH-R) collected from China. Whole-plant bioassays demonstrated that the HZXH-R population exhibited a 21.3-fold resistance to fenoxaprop-P-ethyl compared with sensitive population. Sequencing of the ACCase gene detected no known target-site mutations, thereby excluding target-site mutation-mediated resistance. Treatment with cytochrome P450 inhibitors (piperonyl butyl ether [PBO], malathion, and 1-aminobenzotriazole [ABT]) significantly reduced resistance in HZXH-R, implicating P450 monooxygenases in resistance regulation. Transcriptome sequencing identified six genes that were significantly upregulated and two that were downregulated. RT-qPCR validation confirmed that the P450 gene CYP710A8B showed the highest relative expression in the resistant population. This study demonstrates that the A. fatua population HZXH-R exhibits high-level resistance to fenoxaprop-P-ethyl, with the upregulation of CYP710A8B identified as a potential factor in resistance development. These findings provide a foundation for elucidating the evolutionary mechanisms underlying resistance to ACCase-inhibiting herbicides and for guiding the development of more effective, science-based weed management strategies.

Indexed as

AvenaCytochrome P-450 Enzyme SystemHerbicide ResistanceHerbicidesOxazolesPlant ProteinsPropionatesChinaGene Expression Regulation, PlantCytochrome P-450 Enzyme Systemfenoxaprop ethylHerbicidesOxazolesPlant ProteinsPropionatesAvena fatua LCytochrome P450Fenoxaprop-P-ethylMetabolic resistanceTranscriptome sequencing

Identifiers

PMID41644862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.