Evidence map›Paper›PMID 41644846›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Bone marrow mesenchymal stem cells ameliorate intermittent multiple sclerosis: quantitative cerebellar microscopy and functional analysis in cuprizone-induced mice.

Maedeh Hashemi, Iraj Ragerdi Kashani, Parichehr Pasbakhsh, Babak Ebrahimi, Shiva Amirizadeh, Davood Zarini, Mohammad Hassan Tajik, Reza Asadi-Golshan

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maedeh HashemiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-3203-9842
Iraj Ragerdi KashaniDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-3842-7950
Parichehr PasbakhshDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0009-0009-8659-6442
Babak EbrahimiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-3934-4375
Shiva AmirizadehDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0009-0000-1975-0133
Davood ZariniDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-9264-7738
Mohammad Hassan TajikDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-3813-287X
Reza Asadi-GolshanDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. asadigr@ymail.com.ORCID http://orcid.org/0000-0003-1901-7171

Funding

Tehran University of Medical Sciences and Health Services 55165
6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) results in histological alterations, which in turn leads to behavioral deficits. Bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential in MS. This study aimed to assess whether intranasally delivered BMSCs improve cerebellar structure and motor function in an intermittent cuprizone-induced (INT-CPZ) MS model. 

methodsThe mice were divided into five groups: control, CPZ, CPZ + BMSC, INT-CPZ, and INT-CPZ + BMSC. BMSCs were intranasally delivered at weeks 4 and 10. Motor performance was evaluated using beam walking, pole, and ladder rung walking tests. Stereological analyses were performed to estimate cortex and white matter volumes and Purkinje cell number. 

resultsBMSC treatment improved motor coordination and balance, particularly in INT-CPZ + BMSC mice, which outperformed the CPZ + BMSC group. Stereological results showed reduced volume loss in cortex and white matter and higher Purkinje cell number in BMSC-treated groups, with INT-CPZ + BMSC showing the most pronounced effect. 

conclusionIntranasal BMSC therapy effectively preserved cerebellar structure and motor function in cuprizone-exposed mice. Intermittent cuprizone exposure enhanced BMSC efficacy, likely through mechanisms involving neuroregeneration, and neuroprotection.

Indexed as

CerebellumMesenchymal Stem Cell TransplantationMultiple SclerosisAnimalsCuprizoneDisease Models, AnimalFemaleMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMotor ActivityPurkinje CellsCuprizoneCerebellumIntermittent cuprizoneMesenchymal stem cellMultiple sclerosisStereology

Identifiers

PMID41644846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.