Evidence map›Paper›PMID 41644794›Full record

ArticleInternational journal of obesity (2005)2026

The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens.

Michael Rosenbaum, Kelly C Allison, Maren R Laughlin, Stephanie S Kelley, Joel Nunez-Matos, Michael Rickles, Lillian Chau, Gary Wu, Payman Zamani, Kathryn J Whyte and 3 more

Abstract readMulticenter Study
In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael Rosenbaum *Departments of Pediatrics and Medicine, Division of Molecular Genetics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2835-9202
Kelly C Allison *Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9807-0220
Maren R Laughlin *Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Stephanie S KelleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Joel Nunez-MatosNaomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY, USA.
Michael RicklesDivision of Diabetes and Metabolic Diseases, University of Pennsylvania, Philadelphia, PA, USA.
Lillian ChauDivision of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.
Gary WuDivision of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.
Payman ZamaniDepartment of Medicine (Cardiovascular Medicine), University of Pennsylvania, Philadelphia, PA, USA.
Kathryn J WhyteDepartment of Pediatrics, Division of Molecular Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Rudolph L LeibelDepartments of Pediatrics and Medicine, Division of Molecular Genetics, Columbia University Irving Medical Center, New York, NY, USA. rl232@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-6062-7222
Matthew R HayesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. hayesmr@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-9782-6551
POWERS Consortium

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Predictors of Recidivism to Obesity in Weight-Reduced IndividualsUH3DK128302 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DYMPNA GALLAGHER, RUDOLPH L LEIBEL · 2022 to 2026
$7.0M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI DYMPNA GALLAGHER · 1989 to 2026
$4.3M
Support Mentoring of Early Career Clinical Researchers from Diverse BackgroundsK26DK138418 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DYMPNA GALLAGHER · 2023 to 2026
$483k
NIDDK NIH HHS K26 DK138418NIDDK NIH HHS P30 DK026687NIDDK NIH HHS T32 DK007559NIDDK NIH HHS UH3 DK128302
6 · The paper itself

Abstract

The Physiology Of the WEight Reduced State (POWERS) study is a multi-center clinical trial designed to understand the physiological basis for observed variability in weight regain following intentional weight loss among US adults. The primary dependent variable is weight regain over one year following a 7% or greater supervised weight loss. The overarching design and study organization, along with rationale and history of the POWERS study and outcomes measures are described in accompanying papers. This paper provides the rationale for and description of biospecimens samples that will ultimately inform on the molecular and cellular basis of the physiological variability that contributes to the regulation of energy balance in the weight reduced state. Participants will be 205 healthy adults (n = 205), aged 25-59 years, with body mass index (BMI) 30- ≤ 40 kg/m

Indexed as

Energy MetabolismObesityWeight GainWeight LossAdultBody Mass IndexFemaleHumansMaleMiddle AgedUnited States

Identifiers

PMID41644794
PMCPMC13147548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.