ArticleNature immunology2026
Antigen specificity of clonally enriched CD8
Abstract read
In one paragraph
Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- The neuroimmune network in Alzheimer's and Parkinson's diseases: from mechanistic insights to biomarker-guided immunotherapies and clinical translation.Inflammopharmacology · 2026Review
- Narcolepsy is (not) an autoimmune disease.Nature reviews. Neurology · 2026Review
- Epstein-Barr Virus and Multiple Sclerosis: Mechanistic Insights into Virus-Driven Autoimmunity.Microorganisms · 2026Review
- The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.Immunological reviews · 2026Review
- Article
- AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of Epstein-Barr virus-associated autoimmunity: a comparative overview.Frontiers in immunology · 2026Review
- Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation.Pathogens & immunity · 2026Review
- Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities.Frontiers in immunology · 2026Review
- Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity.Research square · 2025Article
- Intrathecally expanded GZMK+/GZMH+ CD8 T cells targeting EBV antigens may reduce severity of Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity.bioRxiv : the preprint server for biology · 2025Article
- Neuronal expression of β2M and MHC I are essential for peripheral surveillance and targeting of neuron-restricted antigens.Frontiers in neurologyArticle
Corrections and comments
- Update of
Authors and funding
37 authors.
Fumie Hayashi *UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7754-3770
Kristen Mittl *UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ravi Dandekar *UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Josiah GerdtsUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ebtesam HassanUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ryan D SchubertUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3132-5831
Lindsay OshiroUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0009-9773-5524
Rita LoudermilkUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ariele GreenfieldUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Danillo G AugustoUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5665-8547
Gregory HavtonUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Shriya AnumarluUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Arhan SurapaneniUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Akshaya RameshUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Edwina TranUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Kanishka KoshalUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Kerry KizerUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Joanna Dreux3T Biosciences, South San Francisco, CA, USA.
Alaina K Cagalingan3T Biosciences, South San Francisco, CA, USA.
Florian Schustek3T Biosciences, South San Francisco, CA, USA.
Lena Flood3T Biosciences, South San Francisco, CA, USA.
Tamson Moore3T Biosciences, South San Francisco, CA, USA.
Lisa L Kirkemo3T Biosciences, South San Francisco, CA, USA.
Isabelle J FisherUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Tiffany CooperUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Meagan HarmsUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Refujia GomezUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco MS-EPIC Team
Claire D ClellandUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Leah Sibener3T Biosciences, South San Francisco, CA, USA.
Bruce A C CreeUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Stephen L HauserUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4932-4001
Jill A HollenbachUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6572-7962
Marvin Gee3T Biosciences, South San Francisco, CA, USA.
Michael R WilsonUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8705-5084
Scott S ZamvilUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.ORCID http://orcid.org/0000-0003-2720-9915
Joseph J SabatinoUCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. joseph.sabatinojr@ucsf.edu.ORCID http://orcid.org/0000-0002-6804-7441
Funding
The Role of B cells in the Origin and Progression of Multiple SclerosisR35NS111644 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEPHEN L HAUSER · 2019 to 2026
$9.1MThe landscape of HLA mediated variation in health and immunityR01AI158861 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$3.5MCharacterization of T cells in MOG antibody-associated diseaseR01AI170863 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCOTT S ZAMVIL · 2023 to 2026
$3.2MRole of Natural Killer Cell Diversity in Multiple Sclerosis Risk and Disease CourseR01AI169070 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, Paul John Norman · 2022 to 2026
$3.0MDisease relevance of CD20 expression on T cells in multiple sclerosis patientsR01NS092835 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2015 to 2018
$1.7MDetection of disease-relevant CD8+ T cells in Multiple SclerosisK08NS107619 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SABATINO, JOSEPH JOHN · 2019 to 2023
$1.0MA synthetic biosensor of immunologic synapse formation allowing multiplexed T cell antigen discovery for autoimmune neurologic disordersK08AI174061 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSIAH GERDTS · 2023 to 2026
$735kSingle cell RNA-Seq and clonal analysis of CD8+ T cells in MSR21AI142186 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2019 to 2020
$443kThe Role of Ikappa-B Kinase and Glycogen Synthase Kinase 3-beta in Axon DegeneratF31NS074517 · NINDS · WASHINGTON UNIVERSITY · PI GERDTS, JOSIAH · 2011 to 2012
$57kNational Multiple Sclerosis Society (National MS Society) FAN-1608-25607National Multiple Sclerosis Society (National MS Society) RG-2110-38434NIAID NIH HHS K08 AI174061NIAID NIH HHS R01 AI158861NIAID NIH HHS R01 AI169070NIAID NIH HHS R01 AI170863NIAID NIH HHS R21 AI142186NINDS NIH HHS F31 NS074517NINDS NIH HHS K08 NS107619NINDS NIH HHS R01 NS092835NINDS NIH HHS R35 NS111644Uehara Memorial Foundation 202140013U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) K08NS107619U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01AI158861U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01NS092835U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R21AI142186U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R35NS111644
Abstract
CD8
Indexed as
Antigens, ViralCD8-Positive T-LymphocytesEpstein-Barr Virus InfectionsHerpesvirus 4, HumanMultiple SclerosisAdultFemaleHumansLymphocyte ActivationMaleReceptors, Antigen, T-CellAntigens, ViralReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.