Evidence map›Paper›PMID 41644718›Full record

ArticleScientific reports2026

Association between osteoporosis and waitlist mortality in liver transplant candidates.

Arzhang Naseri, Ehsan Shojaeefard, Alireza Keshtkar, Farnaz Atighi, Amirreza Sabahizadeh, Ramina Mofarrah, Marzieh Bakhshayeshkaram, Pedram Talezadeh, Fateme Sadat Sadeghi, Saeedreza Shirzadi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arzhang NaseriEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-4095-2351
Ehsan ShojaeefardEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-7473-4424
Alireza KeshtkarResearch Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.ORCID http://orcid.org/0000-0003-3590-5267
Farnaz AtighiEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0009-0005-2353-7139
Amirreza SabahizadehEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0009-0009-6877-7151
Ramina MofarrahEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-6892-8751
Marzieh BakhshayeshkaramEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Pedram TalezadehEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fateme Sadat SadeghiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-5873-7054
Saeedreza ShirzadiEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-0487-6427
Yasaman KhademEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0003-2416-6999
Mohammad Mahdi DabbaghmaneshEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Taghi HeydariHealth Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hossein DabbaghmaneshEndocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. dabbaghm@sums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is a common comorbidity in end-stage liver disease (ESLD), yet its impact on waitlist survival remains underexplored, particularly in non-Western populations. This prospective cross-sectional study evaluated bone mineral density (BMD) and its association with mortality in 702 adult candidates, including 424 (60.4%) males and 278 (39.6%) females with an overall mean age of 45.13 ± 13.67 years, awaiting their first deceased-donor liver transplantation at a major referral center in Iran. BMD was assessed via dual-energy X-ray absorptiometry (DXA) at the lumbar spine, femoral neck, and total hip. Osteoporosis was present in 43.4% of patients, osteopenia in 36.9%, and only 19.7% had normal BMD. The mean Model for End-Stage Liver Disease (MELD) score was 18.1 ± 6.53. Patients with autoimmune hepatitis (AIH) exhibited the highest prevalence of osteoporosis (53.61%) among all etiologies. Multivariate Cox regression analysis revealed that osteoporosis was independently associated with increased waitlist mortality (HR = 1.90, 95% CI: 1.17–3.07). Conversely, primary sclerosing cholangitis (PSC) was associated with reduced mortality risk (HR = 0.42, 95% CI: 0.19–0.93). These findings underscore the high prevalence of bone disease in ESLD patients, identify AIH as a high-risk etiology for osteoporosis, and establish osteoporosis as a significant predictor of waitlist survival, highlighting the potential value of BMD assessment in pre-transplant risk stratification.

Indexed as

End Stage Liver DiseaseLiver TransplantationOsteoporosisWaiting ListsAbsorptiometry, PhotonAdultBone DensityCross-Sectional StudiesFemaleHumansIranMaleMiddle AgedPrevalenceProspective StudiesRisk FactorsBone mineral densityEnd-stage liver diseaseLiver transplantationOsteoporosisSurvival analysisWaitlist mortality

Identifiers

PMID41644718
PMCPMC12929564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.