Evidence map›Paper›PMID 41644706›Full record

ArticleCommunications chemistry2026

Ionic liquid-coated gold core polymeric nanoparticles for selective neutrophil hitchhiking towards endometriosis treatment.

Priyavrat Vashisth, Lauren T D Clerc, Duoyi Hu, Whitney Jones, Tanveer Shaikh, Christine M Hamadani, Gaya S Dasanyake, Gagandeep Singh, Claylee M Chism, Briana Gamboa and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Priyavrat VashisthDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Lauren T D ClercDepartment of Chemistry & Biochemistry, Presbyterian College, Clinton, SC, USA.
Duoyi HuDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.ORCID http://orcid.org/0000-0002-0441-5129
Whitney JonesDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Tanveer ShaikhDepartment of Chemistry, Mississippi State University, Starkville, MS, USA.ORCID http://orcid.org/0000-0001-9386-7778
Christine M HamadaniDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Gaya S DasanyakeDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Gagandeep SinghDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Claylee M ChismDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Briana GamboaDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Anderson C WallDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Nicholas WhiteheadDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Tyler GilmerDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Sara X EdgecombDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Mercedes C PrideDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Starkville, MS, USA.
Eden E L TannerDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS, USA. eetanner@olemiss.edu.ORCID http://orcid.org/0000-0002-7919-2249

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
National Science Foundation (NSF) 2236629NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Endometriosis is a chronic inflammatory gynecological condition that affects millions of women and people with uteri globally, with limited available treatments. In this work, we explore using ionic liquid (IL)-coated gold core polymeric nanoparticles (NPs), Au-PLGA-IL NPs, for selective neutrophil co-localization for the eventual development of targeted treatment of endometriosis via photothermal therapy. These NPs were synthesized by a modified solvent evaporation method and functionalized with ILs that confer neutrophil selectivity. In vitro biocompatibility was demonstrated using endometrial 12Z cells and a hemolysis assay with human female blood. Ex vivo studies confirmed superior neutrophil targeting ability in human female whole blood, quantified using fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM) to visualize the NP co-localization. Upon near-infrared irradiation (1 W/cm², 5 min), the Au-PLGA-IL NPs induced significant apoptosis in 12Z cells through localized hyperthermia. This study introduces the first system integrating the plasmonic properties of AuNPs with PLGA's biocompatibility, enhanced by functional versatility of ILs, providing a promising platform for endometriosis treatment.

Identifiers

PMID41644706
PMCPMC12982589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.