Evidence map›Paper›PMID 41644653›Full record

ArticleNature neuroscience2026

A generalizable foundation model for analysis of human brain MRI.

Divyanshu Tak, Biniam A Garomsa, Anna Zapaishchykova, Tafadzwa L Chaunzwa, Juan Carlos Climent Pardo, Zezhong Ye, John Zielke, Yashwanth Ravipati, Suraj Pai, Sri Vajapeyam and 15 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Divyanshu TakArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.
Biniam A GaromsaArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.
Anna ZapaishchykovaArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6860-9160
Tafadzwa L ChaunzwaArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.
Juan Carlos Climent PardoArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0009-0007-9110-2043
Zezhong YeArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.
John ZielkeArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8655-3508
Yashwanth RavipatiArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0009-0007-7563-6045
Suraj PaiArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.
Sri VajapeyamBoston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1782-1919
Maryam MahootihaDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mitchell ParkerMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Luke R G PikeMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9622-7442
Ceilidh SmithDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ariana M FamiliarUniversity of Pennsylvania, Philadelphia, PA, USA.
Kevin X LiuBoston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2071-5137
Sanjay PrabhuBoston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0871-115X
Omar ArnaoutBrigham and Women's Hospital, Neurosciences Center, Boston, MA, USA.
Pratiti BandopadhayayBoston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4175-4760
Ali NabavizadehUniversity of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0380-4552
Sabine MuellerDepartment of Neurology, Neurosurgery and Pediatrics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8216-9357
Hugo Jwl AertsArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2122-2003
Raymond Y HuangBoston Children's Hospital, Boston, MA, USA.
Tina Y PoussaintBoston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0814-0791
Benjamin H KannArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA. bkann@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-4313-2754

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5M
Shared Resource Core 2: Clinical Artificial Intelligence CoreU54CA274516 · NCI · DANA-FARBER CANCER INST · PI Benjamin Harris Kann · 2023 to 2026
$8.1M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA165962NCI NIH HHS U54 CA274516
6 · The paper itself

Abstract

Artificial intelligence applied to brain magnetic resonance imaging (MRI) holds potential to advance diagnosis, prognosis and treatment planning for neurological diseases. The field has been constrained, thus far, by limited training data and task-specific models that do not generalize well across patient populations and medical tasks. By leveraging self-supervised learning, pretraining and targeted adaptation, foundation models present a promising paradigm to overcome these limitations. Here we present Brain Imaging Adaptive Core (BrainIAC)-a foundation model designed to learn generalized representations from unlabeled brain MRI data and serve as a core basis for diverse downstream application adaptation. Trained and validated on 48,965 brain MRIs across a broad spectrum of tasks, we demonstrate that BrainIAC outperforms localized supervised training and other pretrained models, particularly in low-data, few-shot, settings and in high-difficulty prediction tasks, allowing for application in scenarios otherwise infeasible. BrainIAC can be integrated into imaging pipelines and multimodal frameworks and may lead to improved biomarker discovery and artificial intelligence clinical translation.

Indexed as

Artificial IntelligenceBrainMagnetic Resonance ImagingNeuroimagingHumans

Identifiers

PMID41644653
PMCPMC13061609

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.