ArticleJournal of the Chinese Medical Association : JCMA2026
Fluorescein tear breakup time predicts pre-lens tear film stability and contact lens comfort.
Article in Journal of the Chinese Medical Association : JCMA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoft contact lenses divide the tear film into pre-lens and post-lens layers. This study evaluated whether pre-lens tear film stability, assessed by fluorescein tear breakup time (TBUT) and noninvasive keratograph breakup time (NIKBUT), predicts subjective comfort.
methodsThis single-center prospective study recruited participants aged 20 to 40 years without ocular diseases. Narafilcon A and verofilcon A contact lenses were used in a crossover design, with participants assigned to wear narafilcon A lenses for 1 week, followed by verofilcon A lenses for another week (Group NV), or the reverse sequence (Group VN). Pre-lens tear film stability was assessed by NIKBUT and fluorescein TBUT on day 1 and day 7. These ocular measurements were correlated with subjective comfort evaluated with the Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) after wearing each lens type.
resultsA total of 82 participants (mean age 29.3 ± 3.3 years; 84% female) completed the study. CLDEQ-8 scores were lower with verofilcon A than with narafilcon A (7.09 ± 5.92 vs 10.21 ± 7.23; p < 0.05). Fluorescein TBUT was consistently longer with verofilcon A than with narafilcon A, both at 15 minutes on day 1 (Group NV: 6.04 vs 3.80 seconds; Group VN: 7.24 vs 3.25 seconds) and at 6 hours on day 7 (Group NV: 4.87 vs 3.03 seconds; Group VN: 5.67 vs 3.15 seconds). NIKBUT did not differ significantly between the two lenses at either time point. CLDEQ-8 scores negatively correlated with fluorescein TBUT for both lens types ( ρ = -0.29 for narafilcon A, p = 0.002; ρ = -0.20 for verofilcon A, p = 0.008).
conclusionVerofilcon A provided better subjective comfort compared with Narafilcon A. Fluorescein TBUT, but not NIKBUT, may serve as a complementary assessment for pre-lens tear film stability and subjective comfort, suggesting that fluorescein TBUT offers distinct clinical value in contact lens practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.