Evidence map›Paper›PMID 41644270›Full record

ArticleJournal for immunotherapy of cancer2026

Shared PRAME epitopes are T-cell targets in NUT carcinoma.

Jeffrey L Jensen, Sara K Peterson, Maria J Sambade, Jessica R Alley, Shawn Yu, Tomoaki Kinjo, Sarah N Bennett, Steven P Vensko, Mitra Shabrang, Johnathan D Debetta and 13 more

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Jeffrey L JensenDivision of Medical Oncology, The University of North Carolina at Chapel Hill Department of Medicine, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0002-8821-4980
Sara K PetersonLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0009-0002-9858-2477
Maria J SambadeLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0002-6223-7324
Jessica R AlleyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shawn YuDepartment of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0003-1951-2949
Tomoaki KinjoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0003-0939-7756
Sarah N BennettLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0002-4605-2776
Steven P VenskoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0001-9399-5999
Mitra ShabrangCurriculum in Toxicology and Environmental Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Johnathan D DebettaDepartment of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Julie K GeyerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0002-9579-379X
Brandon A PriceTempus AI Inc, Chicago, Illinois, USA.ORCID http://orcid.org/0000-0002-2478-2081
Kwangok P NickelDepartment of Human Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Randall J KimpleDepartment of Human Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0001-8336-8000
Rishi S KotechaDepartment of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0003-1836-4075
Laura E HerringLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ian J DavisLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jeremy R WangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0002-0673-9418
Christopher A FrenchDepartment of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Brian KuhlmanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jared M WeissDivision of Medical Oncology, The University of North Carolina at Chapel Hill Department of Medicine, Chapel Hill, North Carolina, USA benjamin_vincent@med.unc.edu alex.rubinsteyn@gmail.com jared_weiss@med.unc.edu.ORCID http://orcid.org/0000-0003-2961-4447
Alex RubinsteynLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA benjamin_vincent@med.unc.edu alex.rubinsteyn@gmail.com jared_weiss@med.unc.edu.ORCID http://orcid.org/0000-0003-2839-2870
Benjamin G VincentLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA benjamin_vincent@med.unc.edu alex.rubinsteyn@gmail.com jared_weiss@med.unc.edu.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Lu Mao · 1985 to 2026
$142.6M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Project 3: Modulation of the head and neck tumor immune microenvironment by targeting the TAM family of receptorsP50CA278595 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2022 to 2026
$12.5M
UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5M
GPU workstation for deep learning-based protein design and cryo-EM data processingR35GM131923 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRIAN A KUHLMAN · 2019 to 2026
$6.1M
Gvl mHA Specific T Cell Responses Prevent AML Relapse Following Allogeneic Stem Cell Transplantation.R37CA247676 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VINCENT, BENJAMIN G · 2020 to 2025
$3.6M
Improving the translational value of head and neck cancer patient-in-mouse modelsR37CA255330 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Randall J. Kimple · 2021 to 2026
$3.5M
Developmental control of chromatin states in cancerR01CA276663 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian J Davis · 2023 to 2026
$1.7M
UNC Immunotherapy Training Grant (IM-TAG)T32CA285257 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan S. Serody · 2023 to 2026
$668k
NCI NIH HHS P30 CA014520NCI NIH HHS P50 CA278595NCI NIH HHS R01 CA276663NCI NIH HHS R37 CA247676NCI NIH HHS R37 CA255330NCI NIH HHS T32 CA285257NIEHS NIH HHS T32 ES007126NIGMS NIH HHS R35 GM131923NIGMS NIH HHS T32 GM086330
6 · The paper itself

Abstract

backgroundNUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing

methodsWe integrated genomics, computational antigen prediction software, targeted immunopeptidomics using single-labeled and double-labeled peptide standards, and gain/loss-of-function genetic experiments on a panel of cell lines (N=5), a patient-derived xenograft, a tissue microarray (N=77), and patient samples from the Tempus AI Sequencing Database harboring evidence of

resultsWe identified

conclusions

Indexed as

Antigens, NeoplasmCarcinomaEpitopes, T-LymphocyteNeoplasm ProteinsNuclear ProteinsT-LymphocytesAnimalsBromodomain Containing ProteinsCell Line, TumorHumansMiceAntigens, NeoplasmBromodomain Containing ProteinsEpitopes, T-LymphocyteNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanPRAME protein, humanAntigen receptor designBispecific T cell engager - BiTEHead and Neck CancerLung CancerT cell Receptor - TCR

Identifiers

PMID41644270
PMCPMC12887479

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.