Evidence map›Paper›PMID 41644269›Full record

ArticleJournal for immunotherapy of cancer2026

Oral immunization with

Xinyuan Lei, Yangle Yu, Charlie Chung, Zhijuan Qiu, Yue Zhang, Timothy H Chu, Xinran Li, Rin Yang, Khadir A Ozler, Mami Burgac and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinyuan Lei *Microbiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Yangle Yu *Microbiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Charlie ChungCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Zhijuan QiuMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Yue ZhangMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Timothy H ChuMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Xinran LiMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Rin YangMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Khadir A OzlerCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Mami BurgacCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Peter M K WestcottCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.ORCID http://orcid.org/0000-0001-9436-4857
Semir BeyazCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA brian.sheridan@stonybrook.edu beyaz@cshl.edu.
Brian S SheridanMicrobiology and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA brian.sheridan@stonybrook.edu beyaz@cshl.edu.ORCID http://orcid.org/0000-0002-3299-5888

Funding

Impact of priming on the generation of intestinal tissue-resident memory T cellsR01AI172919 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Brian S Sheridan · 2022 to 2026
$2.5M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM148331 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Styliani-Anna (Stella) E Tsirka · 2024 to 2026
$695k
NIAID NIH HHS R01 AI172919NIGMS NIH HHS T32 GM148331
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a leading cause of cancer-related death and remains a significant global health challenge. Cancer vaccines have emerged as a promising immunotherapy for long-term tumor control. While

methodsThe ActA and InlB virulence genes were deleted from a mouse-adapted

resultsOral immunization induced a robust CD8 T cell response that was similar in magnitude and phenotype to the fully virulent

conclusionsOral

Indexed as

Cancer VaccinesColorectal NeoplasmsImmunotherapyListeria monocytogenesAdministration, OralAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHumansImmunizationMiceMice, Inbred C57BLCancer VaccinesColorectal CancerImmune Checkpoint InhibitorT cellVaccine

Identifiers

PMID41644269
PMCPMC12878199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.