Evidence map›Paper›PMID 41644194›Full record

ArticleBMJ case reports2026

Olmesartan-related sprue-like enteropathy presenting as severe diarrhoea.

Silvia Suardi, Marco Vicardi, Carlotta Spillere, Paola Leidi, Sara Pecori, Pietro Campagnola, Simonetta Friso, Nicola Martinelli

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvia SuardiDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy silvia.suardi@aovr.veneto.it.ORCID http://orcid.org/0000-0002-1054-105X
Marco VicardiDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy.ORCID http://orcid.org/0009-0007-6012-1524
Carlotta SpillereDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy.
Paola LeidiDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy.
Sara PecoriDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Veneto, Italy.
Pietro CampagnolaGastroenterology Unit, Department of Medicine, University of Verona, Verona, Veneto, Italy.
Simonetta FrisoDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy.
Nicola MartinelliDepartment of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A woman in her 60s with a history of atrial fibrillation, hypertension and dyslipidaemia was admitted to the Intensive Care Unit with hypotension, dehydration and acute kidney injury after 20 days of watery diarrhoea. Although initial investigations did not detect an evident infectious aetiology, a diagnosis of infectious colitis was hypothesised. After supportive care and quick recovery, she was discharged and instructed to resume her prior medications, including olmesartan (used for 1 year) for hypertension. Diarrhoea and renal failure recurred promptly, leading to readmission. Gastroscopy revealed severe villous atrophy and inflammation of the duodenum. However, serological tests for coeliac disease were negative. Olmesartan-related sprue-like enteropathy was diagnosed after discontinuing olmesartan, leading to clinical improvement without a gluten-free diet. This case emphasised the importance of considering iatrogenic causes in severe enteropathy differential diagnosis, particularly olmesartan-related complications in patients presenting with sprue-like symptoms, watery diarrhoea and acute renal failure.

Indexed as

Antihypertensive AgentsCeliac DiseaseDiarrheaImidazolesTetrazolesAcute Kidney InjuryDiagnosis, DifferentialFemaleHumansHypertensionMiddle AgedAntihypertensive AgentsImidazolesolmesartanTetrazolesCardiovascular systemEndoscopyMalabsorptionStomach and duodenum

Identifiers

PMID41644194
PMCPMC12877740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.