Evidence map›Paper›PMID 41644189›Full record

ArticleBMJ open respiratory research2026

Improving the management and outcomes of preschool wheeze: protocol of a prospective multicentre cohort study.

Anne B Chang, Stephanie T Yerkovich, Steven McPhail, Hiran Selvadurai, Vikas Goyal, Shane George, Gabrielle B McCallum, Peter S Morris, Hannah O'farrell, Lesley Versteegh and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anne B ChangChild and Maternal Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia anne.chang@menzies.edu.au.ORCID http://orcid.org/0000-0002-1331-3706
Stephanie T YerkovichCough, Asthma and Airways Group, Australian Centre for Health Services Innovation and School of Medicine, Queensland University of Technology, Brisbane, Queensland, Australia.
Steven McPhailSchool of Public Health and Social Work, Faculty of Health, Queensland University of Technology, 1. Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-1463-662X
Hiran SelvaduraiDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Vikas GoyalAustralian Centre for Health Services Innovation, Kelvin Grove, Queensland, Australia.
Shane GeorgeEmergency Department, Gold Coast University Hospital, Southport, Gold Coast, Australia.
Gabrielle B McCallumChild Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
Peter S MorrisChild Health Division, Darwin, Northern Territory, Australia.
Hannah O'farrellChild and Maternal Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.ORCID http://orcid.org/0000-0002-4241-8697
Lesley VersteeghChild Health Division, Darwin, Northern Territory, Australia.
Jonathan GriggAcademic Unit of Paediatrics, Queen Mary University London, London, UK.
Margaret McElreaQueensland University of Technology Centre for Children's Health Research, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-9078-2357
Sophie WorleySchool of Medicine, Queensland University of Technology Faculty of Health, Kelvin Grove, Queensland, Australia.
Terase YerkovichParent Advisory Group Representative, Cough, Asthma and Airways Group, Australian Centre for Health Services Innovation and School of Clinical Medicine, Queensland University of Technology Faculty of Health, Brisbane, Queensland, Australia.
Leanne Elliot-HolmesAsthma Foundation of the Northern Territory, Darwin, Northern Territory, Australia.
Joanna WilliamsParent Advisory Group Representative, Cough, Asthma and Airways Group, Australian Centre for Health Services Innovation and School of Clinical Medicine, Queensland University of Technology, Brisbane, Queensland, Australia.
Keith GrimwoodSchool of Medicine and Dentistry, Griffith University, Griffith Health, Gold Coast, Queensland, Australia.
Julie M MarchantDepartment of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreschool wheeze and asthma are associated with substantial morbidity and impaired future lung function. Yet, wheeze is unreliably reported with high disagreement (>50%) between parental and physician observations. Objectively defining wheeze and its reversibility could enable an earlier asthma diagnosis and improve preschool wheeze management.Our primary aim is to determine in preschool children (aged 0.5-6 years) suspected of asthma whether adding WheezeScan to routine clinical assessment (vs assessment without WheezeScan) improves the diagnosis of asthma. Our primary hypothesis is that using WheezeScan in preschool children suspected of asthma is associated with increased definitive asthma diagnoses in this age group. Our secondary aims are to (a) examine the effect of using WheezeScan on patient-reported outcomes (PROs) and (b) healthcare costs. Our secondary hypothesis is that using WheezeScan in preschool children suspected of asthma is associated with improved quality of life without incurring additional healthcare costs. METHODS AND ANALYSIS: Our multicentre prospective cohort study involves recruiting 102 preschool children suspected of asthma. WheezeScan, a user-friendly digital device, incorporates artificial intelligence to objectively define wheeze and its response to bronchodilators. Over 6 weeks, parents/caregivers use the WheezeScan two times per day and whenever wheezing is suspected. If wheeze is detected, an inhaled short-acting β ETHICS AND DISSEMINATION: The Children's Health Queensland Human Research Ethics Committee (HREC/23/QCHQ/100691) and the Queensland University of Technology Office of Research Ethics and Integrity approved the study. We will publish and share results with the academic and healthcare communities and relevant patient organisations. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry ACTRN12623000904673.

Indexed as

AsthmaRespiratory SoundsBronchodilator AgentsChildChild, PreschoolFemaleHealth Care CostsHumansInfantMalePatient Reported Outcome MeasuresProspective StudiesQuality of LifeResearch DesignBronchodilator AgentsPaediatric asthmaPaediatric Lung Disaese

Identifiers

PMID41644189
PMCPMC12878444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.