Evidence map›Paper›PMID 41644166›Full record

ArticleBMJ open2026

Evidence-based team intervention to reduce diagnostic errors in anaemia and CKD diagnoses in primary care: protocol for a stepped-wedge cluster RCT.

Zhanna Novikov, Nikhilesh Mehra, Xiao Li, Rebecca Wells, Madelene Ottosen, Kevin Hwang, Elenir B C Avritscher, Charles Green, Kyung Hyun Lee, Xochitl Oguin and 6 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05735314 (A New Combination of Evidence-Based Interventions to Improve Primary Care Diagnostic Safety and Efficiency), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05735314 narecruitingnot on this map

A New Combination of Evidence-Based Interventions to Improve Primary Care Diagnostic Safety and Efficiency: a Stepped Wedge Cluster Randomized Control Trial (RCT)

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2024 to 2026Enrolled450ConditionsAnemia, Decreased Glomerular Filtration RateArmsEnhanced diagnostic team implementing three evidence-based interventions, Usual care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhanna NovikovSchool of Public Health, UTHealth Houston, Houston, Texas, USA zhanna.novikov@uth.tmc.edu.ORCID http://orcid.org/0009-0009-1125-9871
Nikhilesh MehraMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Xiao LiSchool of Public Health, UTHealth Houston, Houston, Texas, USA.
Rebecca WellsSchool of Public Health, UTHealth Houston, Houston, Texas, USA.
Madelene OttosenCizik School of Nursing, UTHealth Houston, Houston, Texas, USA.
Kevin HwangMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Elenir B C AvritscherMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Charles GreenMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Kyung Hyun LeeMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Xochitl OguinMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Mariesa JaneckaMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Mary EspinozaMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Bolanle AdebowaleMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Alejandro ArayaSchool of Biomedical Informatics, UTHealth Houston, Houston, Texas, USA.
Amer WahedMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Eric ThomasMcGovern Medical School, UTHealth Houston, Houston, Texas, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
AHRQ HHS R18 HS028779NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001105
6 · The paper itself

Abstract

introductionDiagnostic errors in primary care are common, particularly in the interpretation and follow-up of abnormal haemoglobin (Hgb) and estimated glomerular filtration rate (eGFR) results. These errors frequently result in missed or delayed diagnoses of serious conditions such as anaemia and chronic kidney disease. This protocol describes a stepped-wedge cluster randomised controlled trial designed to evaluate a novel, evidence-based, team-based intervention aimed at improving diagnostic safety and efficiency. METHODS AND ANALYSIS: The study will be conducted across 12 University of Texas Physicians (UTPs) primary care clinics in Houston, Texas, USA. Adult patients (≥18 years) with newly identified abnormal Hgb or eGFR results will be eligible for inclusion. The intervention integrates automated tracking of abnormal laboratory results, nurse navigators to support patient follow-up and engagement, and clinical pathologists to provide diagnostic guidance to primary care providers. The primary outcome is diagnostic safety, defined as the proportion of patients who receive a correct diagnosis within 6 months. Secondary outcomes include diagnostic efficiency, appropriate test utilisation, cost-effectiveness, patient activation and implementation metrics such as acceptability, fidelity and sustainability. The study will also explore barriers and facilitators to successful implementation using mixed-methods evaluation. ETHICS AND DISSEMINATION: This trial has been approved by the Institutional Review Board at The University of Texas Health Science Center at Houston. Study results will be disseminated through peer-reviewed publications and conference presentations, and findings will be reported to UTP leadership to inform potential system-wide implementation. TRIAL REGISTRATION NUMBER: NCT05735314.

Indexed as

AnemiaDiagnostic ErrorsPatient Care TeamPrimary Health CareRenal Insufficiency, ChronicAdultGlomerular Filtration RateHumansRandomized Controlled Trials as TopicTexasClinical TrialHealth & safetyPatient Care ManagementPrimary Health Care

Identifiers

PMID41644166
PMCPMC12878305

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.