ArticleHeart rhythm2026
Chemical and genetic knockout identifies KCNQ2 as the principal background voltage-gated potassium current in human embryonic kidney 293 cells.
Matthew J O'Neill, Tao Yang, Yuko Wada, Marcia A Blair, Andrew M Glazer
Abstract read
In one paragraphArticle in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Matthew J O'NeillDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Clinical Fellow, Harvard Medical School, Boston, Massachusetts.
Tao YangVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Yuko WadaVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Marcia A BlairVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Andrew M GlazerVanderbilt Center for Arrhythmia Research and Therapeutics (VanCART), Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: andrew.m.glazer@vumc.org.
Funding
Systematically mapping variant effects for cardiovascular genesR01HL164675 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ASHLEY, EUAN A, RODEN, DAN M · 2022 to 2025
$8.1MHigh-throughput discovery of disease-associated ion channel variantsR35GM150465 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Andrew M. Glazer · 2023 to 2026
$1.8MA pipeline for identifying disease-causing variants in transmembrane proteinsR00HG010904 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, ANDREW M. · 2022 to 2024
$737kNHGRI NIH HHS R00 HG010904NHLBI NIH HHS R01 HL164675NIGMS NIH HHS R35 GM150465
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
CRISPREndogenous currentHEK293Ion channelKCNQ2Patch clampPotassium channels
Identifiers
PMID41644077
PMCPMC12908142
What OpenQuestion holds
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LicenceTDM
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