Evidence map›Paper›PMID 41643676›Full record

ArticleCell2026

Molecular architecture of human dermal sleeping nociceptors.

Jannis Körner, Derek Howard, Hans Jürgen Solinski, Marisol Mancilla Moreno, Natja Haag, Andrea Fiebig, Anna Maxion, Shamsuddin A Bhuiyan, Idil Toklucu, Raya A Bott and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Functional and molecular diversity of human C-fibers in pain modulation.Current opinion in supportive and palliative care · 2026
    Review
  4. Article
  5. The mask slipped: wakeable nociceptors express OSMR/SST.Pflugers Archiv : European journal of physiology · 2026
    Article
  6. Article
  7. Skin innervation and itsFrontiers in cellular neuroscience · 2026
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jannis KörnerInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany; Department of Anesthesiology, Uniklinik RWTH Aachen University, Aachen, Germany; Department of Intensive and Intermediate Care, Uniklinik RWTH Aachen University, Aachen, Germany; Scientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany.
Derek HowardKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Hans Jürgen SolinskiDepartment of Experimental Pain Research, MCTN, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Strasse 13-17, 68167 Mannheim, Germany.
Marisol Mancilla MorenoThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Natja HaagScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Center for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen University, Aachen, Germany.
Andrea FiebigScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Research Group Neuroscience, Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University, Aachen, Germany.
Anna MaxionScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Research Group Neuroscience, Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University, Aachen, Germany.
Shamsuddin A BhuiyanDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Idil ToklucuInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany.
Raya A BottInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany.
Ishwarya SankaranarayananThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Diana Tavares-FerreiraThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Stephanie ShiersThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Nikhil N InturiThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Esther EberhardtInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany; Department of Anesthesiology, Uniklinik RWTH Aachen University, Aachen, Germany; Scientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany.
Lisa ErnstInstitute for Laboratory Animal Science and Experimental Surgery, Uniklinik RWTH Aachen University, Aachen, Germany.
Lorenzo BonaguroPRECISE Platform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn and West German Genome Center, Bonn, Germany; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Jonas Schulte-SchreppingPRECISE Platform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn and West German Genome Center, Bonn, Germany; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Marc D BeyerPRECISE Platform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn and West German Genome Center, Bonn, Germany; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Thomas StiehlScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Joint Research Center for Computational Biomedicine (JRCC), Pauwelsstrasse 30, 52074 Aachen, Germany; Institute for Computational Biomedicine and Disease Modelling with Focus on Phase Transitions between Phenotypes, Pauwelsstrasse 30, 52074 Aachen, Germany; Center for Computational Life Sciences (CCLS), RWTH Aachen University, Aachen, Germany.
William RenthalDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ingo KurthScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Center for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen University, Aachen, Germany.
Jenny TigerholmScientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Joint Research Center for Computational Biomedicine (JRCC), Pauwelsstrasse 30, 52074 Aachen, Germany.
Jordi SerraDepartment of Clinical Neurophysiology, King's College Hospital, London SE5 9RS, UK.
Theodore J PriceThe Department of Neuroscience, The University of Texas at Dallas, 800 West Campbell Rd, Richardson, TX 75080, USA.
Martin SchmelzDepartment of Experimental Pain Research, MCTN, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Strasse 13-17, 68167 Mannheim, Germany.
Barbara NamerInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany; Scientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany; Research Group Neuroscience, Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University, Aachen, Germany; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Zentrum Operative Medizin (ZOM), Oberdürrbacher Str. 6, 97080 Würzburg, Germany.
Shreejoy TripathyKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address: shreejoy.tripathy@camh.ca.
Angelika LampertInstitute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany; Scientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany. Electronic address: alampert@ukaachen.de.

Funding

Spatial Core (Moffit)U19NS130617 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI William Russell Renthal, CLIFFORD J WOOLF · 2022 to 2026
$15.5M
Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
Central and Peripheral Mechanisms of Corneal PainU01EY034709 · NEI · UNIVERSITY OF NEW ENGLAND · PI Pedram Hamrah, IAN D MENG · 2022 to 2026
$6.4M
NEI NIH HHS U01 EY034709NINDS NIH HHS U19 NS130608NINDS NIH HHS U19 NS130617
6 · The paper itself

Abstract

Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains elusive, preventing targeted therapy. Using a Patch-seq approach, we combined single-cell transcriptomics, following electrophysiological characterization, with single-nucleus and spatial transcriptomics from pigs and integrated our findings with cross-species and human transcriptomic data. We functionally identified CMis in pig sensory neurons with patch clamp, using adapted protocols from human microneurography. We identified oncostatin M receptor (OSMR) and somatostatin (SST) as marker genes for CMis. Following dermal injection in healthy human volunteers, oncostatin M, the ligand of OSMR, exclusively modulates CMis. Our findings characterize the molecular architecture of human dermal sleeping nociceptors, providing a framework for mechanistic insight into neuropathic pain and potential therapeutic strategies.

Indexed as

NociceptorsSkinSleepAnimalsFemaleGanglia, SpinalHumansMaleNerve Fibers, UnmyelinatedNeuralgiaSensory Receptor CellsSomatostatinSwineTranscriptomeSomatostatindorsal root ganglionmechano-insensitive C-fibersmicroneurographyNav1.9neuropathic painoncostatin MOSMRPatch-seqsingle-cell transcriptomicssleeping nociceptors

Identifiers

PMID41643676
PMCPMC12989165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.