Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Luca Salvatore MengaKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0672-3544
Mayson L A SousaKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4236-5107
Nannan SunKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0009-0005-3144-7969
Rollin RoldanFacultad de Medicina Humana, Universidad de Piura, Lima, Perú.ORCID 0000-0002-1503-3994
Clément BraultIntensive Care Department, Amiens-Picardie University Hospital, Amiens, France.ORCID 0000-0001-6210-2270
Mariangela PellegriniDepartment of Surgical Sciences, Anesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
Matthew KoKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
L Felipe DamianiDepartamento de Kinesiología (Kinesiology career), Facultad de Medicina, Escuela de ciencias de la salud, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-8338-0488
Vorakamol PhoophiboonKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5461-9448
Sebastian DuboKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3206-0433
Fernando VieiraKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Antenor RodriguesKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0064-2826
Mattia DocciKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Lu ChenKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Annia SchreiberKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4073-4001
Arthur S SlutskyKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Martin PostTranslational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-4258-9303
Laurent BrochardKeenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7456-906X
Funding
Canadian Institutes of Health Research (CIHR) PJT152898Canadian Institutes of Health Research (CIHR) PJT156336Canadian Lung Association (CLA)European Respiratory Society (ERS)
6 · The paper itself
Abstract
In acute respiratory distress syndrome (ARDS), regional aeration is often gravity-dependent, with positive end-expiratory pressure (PEEP) recruiting the lung dorsally. Although recruitability can be assessed globally, our aim was to determine the impact of PEEP on regional recruitability and regional strain. To achieve a large representation of recruitability, we studied two preclinical porcine models of acute lung injury [(ALI) 19 symmetrical and 10 asymmetrical ALI], 20 patients with ARDS of mixed etiology (mixed ARDS), and 15 with COVID-19 ARDS. All study subjects underwent a single-breath derecruitment maneuver from high-to-low PEEP to quantify recruitability using the recruitment-to-inflation ratio (R/I). The regional effects of PEEP on strain were assessed using electrical impedance tomography (EIT). Symmetrical ALI animals had the highest R/I (1.39 [1.04-1.66]), followed by mixed ARDS (1.06 [0.70-1.23]), COVID-19 ARDS (0.66 [0.51-0.98]), and asymmetrical ALI (0.45 [0.22-0.85]). Dorsal regions had the highest recruitability (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Global versus regional effects of PEEP on recruitment and strain: insights from preclinical and clinical studies. · full record | OpenQuestion