ArticleUltrasonics sonochemistry2026
Ultrasound-assisted extraction of flavonoids from Cercis chinensis flowers using deep eutectic solvents: optimization, characterization, kinetics and bioactivity.
Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Optimized microwave pretreatment and ultrasound-assisted deep eutectic solvent extraction for efficient valorization of Citrus paradisi peel bioactives.Bioresources and bioprocessing · 2026Article
- Ultrasound-assisted extraction for enhanced recovery and bioactivity of polyphenols from Tuber formosanum.Ultrasonics sonochemistry · 2026Article
- Rapid and Selective Extraction and Detection of Baicalin From Scutellariae Radix Using Magnetic Molecularly Imprinted Polymers.Journal of separation science · 2026Article
- Sequential Pyruvic Acid Pretreatment and Alkaline Extraction of Bamboo Leaf Phenolics: Two-Stage Mass Transfer Kinetics.Foods (Basel, Switzerland) · 2026Article
- Upcycling Black Garlic Peels into Multifunctional Cosmeceutical Extracts: Antioxidants and UV-Shielding via Antimicrobial Natural Deep Eutectic Solvents.Antioxidants (Basel, Switzerland) · 2026Article
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Abstract
This study demonstrates an efficient and eco-friendly method for extracting flavonoids from Cercis chinensis flowers using ultrasound-assisted deep eutectic solvent (UAE-DES) extraction. Among 17 DES systems screened, L-Proline-Lactic acid (DES-11) achieved the best extraction yield (56.53 mg/g), significantly surpassing that of conventional 60 % ethanol extraction (13.65 mg/g). Through Response Surface Methodology optimization of key parameters (ultrasonic temperature, time, and water content), a maximum flavonoid yield of 95.84 mg/g was obtained under ideal conditions: 32 % water, 36 °C, and 31 min. Scanning electron microscopy (SEM) analysis revealed that DES-11 caused substantial cellular disruption, facilitating flavonoid release. Extraction kinetics followed a pseudo-first-order model, with a calculated apparent activation energy of 20.48 kJ/mol, consistent with a diffusion-controlled mechanism. Additionally, 34 flavonoids were identified for the first time in the DES extract using UPLC-timsTOF-MS. The DES extract exhibited superior antioxidant activity in radical scavenging assays compared to the ethanol extract. Furthermore, DES recovery via macroporous resin yielded an 86.64 % flavonoid recovery rate, and the solvent retained over 84.93 % efficiency after four reuse cycles. These results highlight the UAE-DES method as a sustainable and effective strategy for transforming C. chinensis flowers into high-value natural antioxidants.
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