Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels.

Haoran Liu, Klaus Benndorf, Yessenbek K Aldakul, Han Sun

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haoran LiuLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.

Klaus BenndorfInstitut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.

Yessenbek K AldakulLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.

Han SunLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.ORCID https://orcid.org/0000-0002-1655-0838

Funding

Deutsche Forschungsgemeinschaft CRC1078Leibniz Collaborative Excellence project K622/2024Protonation Dynamics in Protein Function RU2518 DynIon

6 · The paper itself

Abstract

Cyclic nucleotide-gated (CNG) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key members of the cyclic nucleotide-activated ion channel family that translate intracellular cyclic nucleotide binding into electrical signals. Functionally, CNG channels drive large inward currents in photoreceptors and olfactory sensory neurons, whereas HCN channels are best known for their roles in pacemaker activity in the heart and the regulation of neuronal excitability. Despite their considerable sequence similarity and conserved overall architecture, these channels exhibit striking differences in ion conductance, K

Indexed as

Cyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnimalsFemaleIon Channel GatingMolecular Dynamics SimulationOocytesPatch-Clamp TechniquesPotassiumXenopus laevisCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassiumCNG channelsHCN channelsion selectivitymolecular dynamics (MD) simulationsselectivity filtersingle‐channel patch‐clamp electrophysiology

Identifiers

PMID41643059

DOI10.1002/advs.202521090

PMCPMC13088309

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.