Evidence map›Paper›PMID 41642952›Full record

ArticleJournal of medicinal chemistry2026

Multiparameter Optimization of

Ahmed S Abdelsamie, Jelena Konstantinović, Andreas M Kany, Christian Schütz, Dominik Kolling, Samira Speicher, Andreas Klein, Roya Shafiei, Mélodie Bouté, Katharina Mundry and 9 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ahmed S AbdelsamieHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.ORCID 0000-0002-5326-4400
Jelena KonstantinovićHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Andreas M KanyHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.ORCID 0000-0001-7580-3658
Christian SchützHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Dominik KollingHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Samira SpeicherHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Andreas KleinHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Roya ShafieiHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Mélodie BoutéLaboratoire d'Excellence Inflamex, Institut National de la Santé et de la Recherche Medicale U1152, Physiopathologie et Épidémiologie des Maladies Respiratoires, Université Paris-Cité, Paris 75006, France.
Katharina MundryInstitute for Food Chemistry, Hannover 30167, Germany.ORCID 0009-0003-9584-6614
Yu Mi ParkHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Brigitta LoretzHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Rolf MüllerHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.ORCID 0000-0002-1042-5665
Jean-Michel SallenaveLaboratoire d'Excellence Inflamex, Institut National de la Santé et de la Recherche Medicale U1152, Physiopathologie et Épidémiologie des Maladies Respiratoires, Université Paris-Cité, Paris 75006, France.
Claus-Michael LehrHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.ORCID 0000-0002-5864-8462
Jesko KoehnkeInstitute for Food Chemistry, Hannover 30167, Germany.
Katharina RoxDeutsches Zentrum für Infektionsforschung (DZIF) e.V., Partner site Braunschweig-Hannover, Braunschweig 38124, Germany.ORCID 0000-0002-8020-1384
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.
Anna K H HirschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken 66123, Germany.ORCID 0000-0001-8734-4663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting the extracellular protease elastase (LasB) of the high-priority pathogen

Identifiers

PMID41642952
PMCPMC12951441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.