ArticlePloS one2026
Bedside measurement of microcirculation in critically ill patients: A scoping review protocol.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Optimizing In Vivo Perfusion Assessment by Laser Doppler Flowmetry-Effects of Probe Geometry and Signal Normalization.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrocirculatory dysfunction is a pivotal factor in the pathophysiology and prognosis of critically ill patients. While traditional resuscitation primarily emphasizes macrocirculatory parameters such as mean arterial pressure (MAP), emerging evidence indicates that maintaining a normal MAP alone does not guarantee adequate microvascular perfusion. As a result, bedside evaluation of microcirculation has garnered increased interest as a supplementary method to hemodynamic monitoring.
objectiveThis scoping review aims to systematically map and categorize existing bedside tools and technologies used to assess microcirculation in critically ill patients. The review will summarize their clinical applications, advantages, limitations, and integration into intensive care practice, and identify key evidence gaps to guide future research.
methodsIn accordance with the Joanna Briggs Institute (JBI) framework and the PRISMA-ScR guidelines, a comprehensive literature search will be conducted across MEDLINE, Scopus, Web of Science, Embase, CINAHL, the Cochrane Library, and ProQuest. Additionally, the grey literature search will be complemented by searches of trial registries such as ClinicalTrials.gov and the WHO ICTRP. Eligible studies will encompass all primary research involving critically ill patients evaluated for microcirculatory function at the bedside within intensive care units (ICUs). Data extraction and synthesis will adhere to an inductive-deductive thematic approach based on Braun and Clarke's methodology, complemented by the PAGER framework to identify patterns, advances, gaps, and evidence pertinent to clinical practice.
conclusionBy mapping the landscape of bedside microcirculatory assessment tools, this review will support the translation of microcirculatory monitoring from research to clinical practice, thereby promoting physiologically guided, individualized management in critically ill patients. REGISTRATION: This protocol is prospectively registered in OSF.io.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.