Evidence map›Paper›PMID 41642752›Full record

ArticleBiopsychosocial science and medicine2026

Attachment Insecurity and Well-Being in Dementia Spousal Caregivers: The Moderating Role of Marital Satisfaction.

Vincent D Lai, Daniel L Argueta, Kelly N Brice, Bryan T Denny, Charles Green, Luis D Medina, Jensine Paoletti-Hatcher, Paul E Schulz, Jennifer M Stinson, E Lydia Wu-Chung and 2 more

Abstract read
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Article in Biopsychosocial science and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Daniel L Argueta
Kelly N Brice
Bryan T Denny
Charles Green
Luis D Medina
Jensine Paoletti-Hatcher
Paul E Schulz
Jennifer M Stinson
E Lydia Wu-Chung
Cobi J Heijnen
Christopher P Fagundes

Funding

Individual differences in dementia spousal caregiver burden: A biobehavioral approach revisionR01AG062690 · NIA · RICE UNIVERSITY · PI FAGUNDES, CHRISTOPHER PAUL · 2019 to 2023
$4.3M
Biopsychosocial influences on cognitive function in dementia spousal caregiversF32AG090098 · NIA · RICE UNIVERSITY · PI Kelly N Brice · 2024 to 2026
$242k
Employment Status, Psychosocial Functioning, and Chronic Inflammation Among Dementia Spousal CaregiversF32AG079624 · NIA · RICE UNIVERSITY · PI PAOLETTI, JENSINE · 2022 to 2024
$151k
NIA NIH HHS F32 AG079624NIA NIH HHS F32 AG090098NIA NIH HHS R01 AG062690NIOSH CDC HHS T03 OH008435
6 · The paper itself

Abstract

objectiveCaregivers for spouses with Alzheimer disease and related dementias (AD/ADRD) who exhibit insecure attachment orientations-specifically, greater attachment anxiety and/or avoidance-are at risk for poorer physical and mental well-being. Marital satisfaction, or caregivers' general evaluations of their relationship with their spouses, may buffer this risk. We tested marital satisfaction as a potential buffer of the associations between attachment orientation and psychological and physiological indices of well-being.

methodsA cross-sectional sample of 264 AD/ADRD spousal caregivers completed self-report measures of attachment orientation, marital satisfaction, and depressive symptoms and provided blood samples. We conducted multiple regression models to test study hypotheses.

resultsGreater attachment avoidance was associated with more depressive symptoms ( P = .002) and higher lipopolysaccharide (LPS)-stimulated cytokine production ( P = .001). The associations between attachment avoidance and depressive symptoms ( P = .045) or LPS-stimulated cytokine production ( P = .028) were weaker at higher levels of marital satisfaction. Greater attachment anxiety was associated with more depressive symptoms ( P < .001), and, unexpectedly, this association was stronger as caregivers reported higher levels of marital satisfaction ( P = .028). Marital satisfaction did not moderate the association between attachment anxiety and LPS-stimulated cytokine production ( P = .20).

conclusionsOur work contributes to the body of research examining psychosocial factors that shape well-being among caregivers. Our findings may inform future interventions focusing on the marital relationship to improve caregiver well-being; although these interventions may benefit avoidantly attached caregivers, anxiously attached caregivers may benefit most from intervention approaches tailored to their specific attachment orientation.

Indexed as

CaregiversDementiaDepressionMarriageObject AttachmentPersonal SatisfactionSpousesAgedAnxietyCross-Sectional StudiesCytokinesFemaleHumansMaleMiddle AgedPsychological Well-BeingCytokinesattachmentdementia spousal caregiversdepressive symptomsmarital satisfactionstimulated cytokine production

Identifiers

PMID41642752
PMCPMC13340580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.