Evidence map›Paper›PMID 41642644›Full record

ArticleThe Journal of general virology2026

Mutant knock-in mice display enhanced susceptibility to pure prion protein fibrils.

Daniel J Walsh, Heidi Standke, Allison Kraus, Joel C Watts, Surachai Supattapone

Abstract read
In one paragraph

Article in The Journal of general virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel J WalshDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA.
Heidi StandkeDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Allison KrausDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Joel C WattsTanz Centre for Research in Neurodegenerative Diseases and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Surachai SupattaponeDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Mapping Molecular Pathways that Control Prion MetabolismR37NS125431 · NINDS · DARTMOUTH COLLEGE · PI Surachai Supattapone · 2022 to 2026
$3.5M
Structural Mechanism of Mammalian Prion InfectivityR01NS118796 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI, ZILM, KURT WILLIAM · 2020 to 2024
$2.8M
Novel Therapeutic Strategies Targeting Malleability of Wild-Type and Mutant PrionsR01NS117276 · NINDS · DARTMOUTH COLLEGE · PI SUPATTAPONE, SURACHAI · 2020 to 2025
$2.4M
NIGMS NIH HHS P20 GM113132NINDS NIH HHS R01 NS117276NINDS NIH HHS R01 NS118796NINDS NIH HHS R37 NS125431
6 · The paper itself

Abstract

Prion diseases manifest clinically in three different forms. Sporadic and infectious forms of prion disease are caused by the conversion of WT, cellular prion protein (PrP

Indexed as

Prion DiseasesPrion ProteinsPrPSc ProteinsAnimalsBrainGene Knock-In TechniquesMiceMice, TransgenicMutationPrion ProteinsPrPSc Proteinsfatal familial insomniafCJDfibrilgeneticmutantprion

Identifiers

PMID41642644
PMCPMC12877565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.