Evidence map›Paper›PMID 41642540›Full record

ArticleJournal of cardiovascular translational research2026

PAD-associated Genetic Variants are More Strongly Associated with Surgical Intervention than Premature Onset.

Jiaqi Hu, Dana Alameddine, He Wang, Arya Mani, Curt Scharfe, Yong-Hui Jiang, Michael F Murray, Cassius I Ochoa Chaar, Andrew T DeWan

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaqi HuDepartment of Chronic Disease Epidemiology, Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, 1 Church Street, 6th Floor, New Haven, Connecticut, 06510, USA.
Dana AlameddineDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT, 06510, USA.
He WangDepartment of Pathology, Yale School of Medicine, New Haven, CT, 06510, USA.
Arya ManiDepartments of Internal Medicine and Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.
Curt ScharfeDepartment of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.
Yong-Hui JiangDepartment of Genetics, Neuroscience, and Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA.
Michael F MurrayIcahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, 1425 Madison Avenue, New York, NY, 10029, USA.
Cassius I Ochoa ChaarDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT, 06510, USA.
Andrew T DeWanDepartment of Chronic Disease Epidemiology, Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, 1 Church Street, 6th Floor, New Haven, Connecticut, 06510, USA. andrew.dewan@yale.edu.ORCID 0000-0002-7679-8704

Funding

Society for Vascular Surgery Clinical Research Seed Grant
6 · The paper itself

Abstract

This study explored the association between 19 peripheral artery disease (PAD)-associated variants and PAD severity. We classified PAD cases into 4 groups with increasing levels of severity based on age of PAD diagnosis and surgical status. Genetic association analysis for PAD severity and markers was conducted using REGENIE, and a 19-variant polygenic risk score (PRS) was developed to further evaluate the associations with severity subtypes. Two SNPs (rs4722172 and rs505922) showed stronger odds ratios (ORs) with more severe subtypes. The 19-variant PRS was significantly higher in surgical compared to non-surgical groups (OR = 1.14, 95% CI: 1.08, 1.20; p-value = 5.85 × 10

Indexed as

Peripheral Arterial DiseasePolymorphism, Single NucleotideVascular Surgical ProceduresAgedAge of OnsetFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedOdds RatioPhenotypeRisk AssessmentRisk FactorsGenetic riskPeripheral artery diseasePRSSeverity

Identifiers

PMID41642540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.